Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Does plaquenil help with light sensitivity How long does plaquenil take to work for hives Faf in plaquenil toxicity Aug 10, 2016 Chloroquine is administered in loading dose in malaria Chloroquine is well absorbed after oral administration. It is extensively tissue bound and sequestrated by tissues particularly liver, spleen, kidney it has got large apparent volume of distribution So it is given in loading dose to rapidly achieve. Pharmacology of Chloroquine Mechanism of Action As mentioned earlier, chloroquine is effective against the erythrocytic form of the Plasmodium parasite. Chloroquine is able to accumulate at very high concentrations within the acid compartments of the parasite. At present, the absolute mechanism of accumulation of the drug is still under debate. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of action slideshare Chloroquine mechanism of drug action and resistance in., Medicinal Chemistry of Antimalarial Drugs Chloroquine headachePlaquenil flu shotHydroxychloroquine and sunlight Chloroquine works to treat malaria by killing the Plasmodium parasites that cause the infection. This eMedTV segment describes chloroquine's mode of action and provides a link to more detailed information on this medication. Mode of Action of Chloroquine - Malaria Home Page. Chloroquine - FDA prescribing information, side effects and uses. Chloroquine - YouTube. Stereoselectivity in chloroquine body disposition could be responsible for this discrepancy. Chloroquine binding to plasma proteins is stereoselective, favouring S+-chloroquine 67% vs 35% for the R-enantiomer. Hence, unbound plasma concentrations are higher for R−-chloroquine. Slater AF 1993 Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol Ther 57 203–235. View Article Google Scholar 9. Sullivan DJ Jr, Matile H, Ridley RG, Goldberg DE 1998 A common mechanism for blockade of heme polymerization by antimalarial quinolines. Chloroquine Its Mechanism of Action Upon Immune Phenomena. Data were presented to indicate that the antimalarial drug chloroquine does not interfere with the normal antibody response in rabbits nor does it depress the levels of formed antibody.