If you’ve had it for some time, you may even be experiencing the joint deformities that can occur as RA progresses. As you know, any joint deformity can take a significant toll on your joint function as well as your overall quality of life. Chloroquine cancer therapy Retinae eye drops hydroxychloroquine Methotrexate in combination with other DMARDs is not superior to methotrexate alone for remission induction with moderate-to-high-dose glucocorticoid bridging in early rheumatoid arthritis after 16 weeks of treatment the CareRA trial. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Leisurely pursuits like gardening or taking long walks may have lost their appeal as well, largely as a result of the pain and inflammation these joint-based movements can trigger. RA usually attacks the joints of the hands and feet first, which means even simple activities like tying a shoe, brushing your teeth, combing your hair, or getting dressed in the morning can become painful enterprises. Plaquenil and methotrexate for rheumatoid arthritis Methotrexate and plaquenil -, Rheumatoid Arthritis Treatment Options Johns Hopkins. Is retinal toxicity from plaquenil reversibleChloroquine how does it workChloroquine mechanism of action iodineHydroxychloroquine syrup The distinction between using methotrexate to treat cancer and to treat rheumatoid arthritis is important. Technically speaking, methotrexate is a “cancer drug” — and it’s used to treat different kinds of cancer, including breast cancer. That’s because methotrexate attacks fast-dividing cells, which include cancer cells. Common Questions About Taking Methotrexate for Rheumatoid.. Hydroxychloroquine Plaquenil. RA and Hydroxychloroquine How Effective is it for.. Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will.