Additionally, another exception occurred while executing the custom error page for the first exception. To investigate the application of ultra-widefield fundus autofluorescence (UWF-FAF) imaging in evaluating hydroxychloroquine (HCQ) retinopathy and to report peripheral autofluorescence findings in Asian patients with this condition. Patient population: 58 eyes of 29 patients with HCQ retinopathy. Chloroquine dose for prophylaxis Chloroquine primaquine side effects Fundus autofluorescence can reveal early parafoveal or extramacular photoreceptor damage as an area of hyper-autofluorescence that may precede thinning on SD-OCT. Later on, this area can be hypo-autofluorescence as the RPE becomes atrophic. Multifocal ERG may reveal depression in the parafoveal or extramacular area in early retinopathy. Hydroxychloroquine Retinopathy-Fundus Autofluorescence. Fundus autofluorescence image of a 46-year-old woman with systemic lupus erythematosus who had taken chloroquine for 17 years at a dosage of 500 mg/d. Based on her actual body weight, which was ideal, she had been overdosed at 8.8 mg/kg/d and had received a cumulative dose of 3102 g of. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. The sensitivities of detecting retinopathy using the 2 modalities were compared. Observation procedures: UWF-FAF imaging was performed, and the images were compared to conventional FAF images obtained using a confocal digital ophthalmoscope. Plaquenil maculopathy fundus autofluorescence Unusual Fundus Autofluorescence Appearance in a Patient with., Hydroxychloroquine Retinopathy-Fundus Autofluorescence. 4 aminoquinolines chloroquineChloroquine pretreatment before transfectionPlaquenil and rashCan plaquenil cause eye redness Ivocal signs of chloroquine maculopathy bilateral peri-central scotoma in the visual fields, structural alterations of the macula in the optical coherence tomography but normal or atypical findings as to fundus autofluorescence imaging. Results In all patients, optical coherence tomography showed perifoveal thinning and subtle alterations of the outer retinal layers. In one patient, the. FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE MACULOPATHY. Hydroxychloroquine Plaquenil Toxicity and.. Early Plaquenil Toxicity Detected without Bull’s Eye.. Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Hydroxychloroquine HCQ retinopathy can result in permanent vision loss. In early stages of HCQ retinopathy, patients are usually asymptomatic with preservation of visual acuity. We aspire that our review, in conjunction with the American Academy of.