The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). Chloroquine otc Folic acid and plaquenil Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. The doctor then kept me on my plaquenil and added Leflunomide Arava to replace the methotrexate. My mouth sores went away and I quit having the days of sickness from the methotrexate. There may be something better out there, but for me the Arava has made a big difference. After 2 years of taking MTX, Sulfasalazine and Hydroxychloroquine in combination my new Rheumy has determined that there aren't having enough effect as a combination and wants to take me off the Sulfa and substitute Leflunomide. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine Leflunomide vs Methotrexate Comparison -, Anyone used plaquenil and arava which is better? DailyStrength Sjorens syndrome plaquenilWhat is the maximum dose of plaquenilPlaquenil mefioquinePlaquenil multiple sclerosisStarting plaquenil The U. S. Food and Drug Administration FDA is adding information on severe liver injury to the Boxed Warning of Arava leflunomide – a drug used to treat rheumatoid arthritis - to. FDA Drug Safety Communication New boxed warning for severe liver.. Anyone on Leflunomide, Hydroxychloroquine and MTX? - NRAS. Methotrexate or Arava? -. Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. Patients using biological drugs and hydroxychloroquine exhibited more signs and symptoms of anxiety, with averages above the established cutoff, followed by patients using methotrexate and, finally, patients treated with leflunomide, who displayed the most few signs of anxiety.