It's the first drug most doctors prescribe after you’re diagnosed. It will help ease symptoms like joint pain, fatigue, redness, and swelling. Plaquenil for urticaria Hydroxychloroquine 200 mg tablet cost Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss day, been taking for over a year now but although it helps with some of the pain. I have to have steroid. Methotrexate interrupts the process that causes RA inflammation, which damages your joints and organs over time. It may also help prevent damage to your organs and joints. Does hydroxychloroquine always help when taking methotrexate Methotrexate and Humira DailyStrength, Which would you pick and why? - Plaquenil or Methotrexate Can finger joints heal lupus long term usage plaquenilChloroquine acidity Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Hydroxychloroquine Side-effects, uses, time to work. Does anyone take methotrexate and hydroxychloroquine. - NRAS. Combination therapy with methotrexate and hydroxychloroquine.. Fortunately, the problems seen by people taking this medication are usually very mild. Serious side effects are rare. Overall, most people who have any noticeable side effects from hydroxychloroquine experience diarrhea or nausea. These usually get better after the person adjusts to the medication, and taking the drug with food can help, as well. If you take methotrexate by injection, it will be given into a layer of fat between the skin and muscle. This is known as a subcutaneous injection. This injection can be given by a health professional, but often you’ll be shown how to do the injection yourself using a syringe or an injector pen. This will help you avoid skin reactions. It can take 3 to 6 weeks to start to feel your methotrexate work. It takes even longer -- 12 weeks -- to get the full effects. Your doctor will test your blood often to check on how well your treatment works and to make sure it’s safe for organs such as your liver.