They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Chloroquine 250 mg tab Chloroquine gram negative or positive Estradiol plaquenil combination Chloroquine-primaquine-phosphate tablets Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Immunity -- your body’s defense system -- tends to get weaker with age. “Just as you probably can’t run as fast as you used to in your 20s, your immune system doesn’t work as well as it used to,” says Aaron E. Glatt, MD, chairman of the department of medicine at South Nassau Communities Hospitals. But fear not. But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system, potentially causing infections, low blood counts, and liver toxicity. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does plaquenil weaken the immune system Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, The Immunity Challenge How aging affects your immune system Plaquenil causing dry mouthCrest syndrome hydroxychloroquineAralenePlaquenil and visionDescribe eye tests for plaquenil Evhead17. I'm not a healthcare provider, but I do take Plaquenil and just found out from another user of it that it does suppress the immune system. I didn't know that when I started taking it for Sjogren's in November 2011. In January 2012, I had a horrible cold, stomach flu and then SHINGLES. Does plaquenil cause shingles, does it suppress the immune.. Protecting your eyesight when taking Plaquenil Lupus Foundation of.. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. They use plaquenil to suppress your immune system to slow it down, not speed it up. Your system is working overtime, so IMO, its stronger and that causes the problems we have the body needs a nice nuetral immune system working normally. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and Immune system disorder - from FDA reports Summary Immune system disorder is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain.