Been waiting for a rheumatology appointment for 13 weeks so far which is giving me too much time to think!! After 3 years of joint pain and fatigue and constantly getting a negative rheumatoid factor blood test result, on my last big flare up in Feb the bloods came back as positive for rheumatoid factor with my GP. Chloroquine tlr9 inhibitor Plaquenil side effect on eyes Hydroxychloroquine is considered safe in all trimesters of pregnancy. Due to the high risk of flare in systemic lupus erythematosus when discontinuing this medication, continued Plaquenil use is advised in these patients during pregnancy. It spread to both feet and now my hands, hips and knees. I also experience weakness in my arms coming from my elbows. So I have a new PCP, and went to see her and she ran all the tests and it shows positive Rheumatoid factor 18 and elevated C- reactive protein. It does not show elevated uric acid, which is associated with gout. Plaquenil vs Methotrexate. plaquenil is best taken with a meal as otherwise it may cause nausea. methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects. Rheumatoid factor, ccp, and another one I. I am worried that when the appointment for the consultant finally comes through my rheumatoid factor will be negative again? Although certain joints are now permanently painful most swelling has gone down. Rheumatoid factor dropped plaquenil Hydroxychloroquine Use Is Associated With Decreased Incident., Plaquenil rheumatoidarthritis Plaquenil tab 200mg costHydroxychloroquine 200 mg reviewsWhat does hydroxychloroquine do for lupus I still have flares now and then, but work full time. I have not had problematic side effects from the Plaquenil or MTX, but the steroids caused weight gain and some hair loss besides what was caused by the arthritis. I am still negative for the RA factor, but have suffered with bilateral trochanteric bursitis and pain at the sides of my knees. Plaquenil for RA?" Rheumatoid Arthritis Community.. Plaquenil vs Methotrexate rheumatoid. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. I was diagnosed with RA a month ago and am returning to my Rheumatologist tomorrow to discuss treatment options. The doctor said that given where I am right now constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound, she gave me a choice of starting on either Plaquenil or Methotrexate. Sjogren's syndrome is an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It also associated with rheumatic disorders such as rheumatoid arthritis, and it is rheumatoid factor positive in 90 percent of cases. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage.