It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Plaquenil induced cardiomyopathy Hydroxychloroquine cause weight gain Ok I'll admit I'm impatient to feel better and get on with my life. My question is, how long does it take for plaquenil to make an impact? And does it really help the fatigue? That's my biggest issue. I've been on it for about three and a half weeks. Thanks! Danni TreatmentRisksClinical significanceContraindicationsPreventionResultsBenefitsPrognosis I was just wondering how long it took for Plaquenil to start working for you? I've been on it for about a month now, and it hasn't worked for me yet, but I know that it can take up to 4 months to kick in. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. How long plaquenil take to work Plaquenil - does it take long time to work? - Lupus - Inspire, Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Benefits of plaquenilPlaquenil corneal toxicity How long is it supposed to it take for plaquenil hydroxychloroquine to get rid of the lupus butterfly rash? 1 doctor responded I had a skin rash from plaquenil hydroxychloroquine. How long does it take for plaquenil hydroxychloroquine to.. How long until Plaquenil started working?. Plaquenil -. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under.