Severe inflammation; immunosuppression Adults: Dosage individualized based on diagnosis, severity of condition, and response. Amphotericin B, mezlocillin, piperacillin, thiazide and loop diuretics, ticarcillin: additive hypokalemia Aspirin, other nonsteroidal anti-inflammatory drugs: increased risk of GI discomfort and bleeding Cardiac glycosides: increased risk of digitalis toxicity due to hypokalemia Cyclosporine: therapeutic benefits in organ transplant recipients, but with increased risk of toxicity Erythromycin, indinavir, itraconazole, ketoconazole, ritonavir, saquinavir: increased prednisone blood level and effects Hormonal contraceptives: impaired metabolism and increased effects of prednisone Isoniazid: decreased isoniazid blood level Live-virus vaccines: decreased antibody response to vaccine, increase risk of adverse effects Oral anticoagulants: reduced anticoagulant requirements, opposition to anticoagulant action Phenobarbital, phenytoin, rifampin: decreased prednisone efficacy Salicylates: reduced salicylate blood level Somatrem: inhibition of somatrem's growth-promoting effects Theophylline: altered pharmacologic effects of either drug Drug-diagnostic tests. CNS: headache, nervousness, depression, euphoria, personality changes, psychosis, vertigo, paresthesia, insomnia, restlessness, seizures, meningitis, increased intracranial pressure CV: hypotension, hypertension, vasculitis, heart failure, thrombophlebitis, thromboembolism, fat embolism, arrhythmias, shock EENT: posterior subcapsular cataracts (especially in children), glaucoma, nasal irritation and congestion, rebound congestion, sneezing, epistaxis, nasopharyngeal and oropharyngeal fungal infections, perforated nasal septum, anosmia, dysphonia, hoarseness, throat irritation (all with long-term use) GI: nausea, vomiting, abdominal distention, rectal bleeding, esophageal candidiasis, dry mouth, esophageal ulcer, pancreatitis, peptic ulcer GU: amenorrhea, irregular menses Hematologic: purpura Metabolic: sodium and fluid retention, hypokalemia, hypocalcemia, hyperglycemia, decreased carbohydrate tolerance, diabetes mellitus, growth retardation (in children), cushingoid effects (with long-term use), hypothalamic-pituitary-adrenal suppression (with systemic use longer than 5 days), adrenal suppression (with high-dose, long-term use) Musculoskeletal: muscle weakness or atrophy, myalgia, myopathy, osteoporosis, aseptic joint necrosis, spontaneous fractures (with long-term use), osteonecrosis, tendon rupture Respiratory: cough, wheezing, bronchospasm Skin: rash, pruritus, contact dermatitis, acne, striae, poor wound healing, hirsutism, thin fragile skin, petechiae, bruising, subcutaneous fat atrophy, urticaria, angioedema Other: bad taste, increased or decreased appetite, weight gain (with long-term use), facial edema, aggravation or masking of infections, hypersensitivity reaction Drug-drug. • Hypersensitivity to drug, other corticosteroids, alcohol, bisulfite, or tartrazine (with some products) • Systemic fungal infections • Live-virus vaccines (with immunosuppressant doses) • Active untreated infections (except in selected meningitis patients) Use cautiously in: • diabetes mellitus, glaucoma, renal or hepatic disease, hypothyroidism, cirrhosis, diverticulitis, nonspecific ulcerative colitis, recent intestinal anastomoses, inflammatory bowel disease, thromboembolic disorders, seizures, myasthenia gravis, heart failure, hypertension, osteoporosis, hypothyroidism, ocular herpes simplex, immunosuppression, emotional instability • pregnant or breastfeeding patients • children under age 6. Calcium, potassium, thyroid I uptake, thyroxine, triiodothyronine: decreased levels Cholesterol, glucose: increased levels Nitroblue tetrazolium test for bacterial infection: false-negative result Drug-herbs. Alfalfa: activation of quiescent systemic lupus erythematosus Echinacea: increased immune-stimulating effects Ephedra (ma huang): decreased drug blood level Ginseng: potentiation of immunomodulating effect Licorice: prolonged drug activity Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers Check for signs and symptoms of depression and psychosis. • Assess blood glucose level carefully in diabetic patient. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals. Buy retin a liquid Buy viagra czech republic Buy flagyl 500mg online Where to buy kamagra oral jelly in australia Prednisone is a medication designed to prevent the release of substances in the body that can cause inflammation, thereby lowering redness. Prednisone definition a chemical derivative, CHO, of cortisone, but with fewer side effects, used in the treatment of arthritis and certain allergic and inflammatory. PREDNISOLONE prednisolone Tablets. DESCRIPTION. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily. In contrast to anabolic steroids (used by “bodybuilders”), corticosteroids are used in inflammatory conditions for their anti–inflammatory effects. They have a rapid onset of action, and profoundly affect many parts of the immune system as well as most other body systems. Corticosteroids are a cornerstone of treating most types of vasculitis, and are often used in combination with other immunosuppressive medications. Many of the side–effects of steroids are predictable. All are related to: 1) the amount of steroid a patient takes in his/her daily dose, and 2) the length of time the patient remains on the medication. We emphasize that not all side–effects occur in all patients. Despite the numerous potential side–effects of corticosteroids listed below, their introduction into patient care 50 years ago revolutionized the treatment of many diseases, including vasculitis. These example sentences are selected automatically from various online news sources to reflect current usage of the word 'prednisone.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Prednisone meaning Prednisone Definition of Prednisone by Merriam-Webster, Prednisone dictionary definition prednisone defined - YourDictionary Amoxicillin metabolismZoloft hungerZoloft wellbutrin side effectsAzithromycin how long does it take to work Prednisone can help prevent organ rejection after a kidney transplant because of its ability to suppress the immune system. But the medication also has potential. What You Need To Know About Prednisone National Kidney.. Prednisolone Prednisolone Tablets Side Effects, Interactions.. Prednisolone definition and meaning Collins English Dictionary. Prednisone Prednisone Intensol, Rayos is a drug used for suppressing the immune system and inflammation such as asthma, severe psoriasis, lupus. One of the numerous potential side–effects of prednisone and other forms of. In avascular necrosis or osteonecrosis, meaning “bone death” of the hip, the. Nov 28, 2018. Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn about side effects, interactions and indications.