The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. Autofluorescence test for plaquenil toxicity Hydroxychloroquine in chikungunya Section of the Plaquenil hydroxychloroquine drug label regarding cardiac effects, including cardiomyopathy and QT prolongation, and hypoglycemia. and for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. Make sure your doctor knows if you had a heart rhythm problem such as QT prolongation. This medicine may cause muscle and nerve problems. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. QT Interval prolongation Hydroxychloroquine has the potential to prolong the QTc interval in patients with specific risk factors. Hydroxychloroquine should be used with caution in patients with congenital or documented acquired QT prolongation and/or known risk factors for prolongation of the QT internal such as • advanced age, The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. Hydroxychloroquine qt prolongation The cardiotoxicity of antimalarials, Hydroxychloroquine Oral Route Precautions - Mayo Clinic Hydroxychloroquine sulfate mechanism of actionHydroxychloroquine shelf life Hydroxychloroquine is associated with several rare but serious adverse reactions that may warrant immediate discontinuation of the medicine. Serious adverse reactions include ophthalmological, cardiomyopathy and QT prolongation, haematological, and neurological and neuromuscular reactions. Risks of Hydroxychloroquine - Medsafe. DATA SHEET 1 PRODUCT NAME 2 QUALITATIVE AND QUANTITATIVE.. Drugs Causing QT Prolongation • LITFL Medical Blog • ECG Library Basics. Heart problems like heart failure and a certain abnormal heartbeat prolonged QT interval have happened with hydroxychloroquine. Sometimes, these heart problems have been deadly. Call your doctor right away if you have a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in. HS34-HS40. ABSTRACT QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. The majority of cases have occurred in patients taking an offending agent with multiple identifiable risk factors for corrected QT QTc prolongation. Hydroxychloroquine may cause a condition that affects the heart rhythm QT prolongation. QT prolongation can rarely cause serious rarely fatal fast/irregular heartbeat and other symptoms such as severe dizziness, fainting that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation.