Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and bursitis Arthritis medicine hydroxychloroquine Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Oct 01, 2014 Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. In line with this notion, cancer cells from poorly vascularized, hypoxic tumor regions contain elevated amounts of autophagosomes, allowing them to deal with limited oxygen supplies.93 Moreover, several cell lines obtained from established cancers not only are characterized by increased levels of autophagy in baseline conditions, but also appear to require an elevated autophagic flux for the maintenance of metabolic functions and proliferation.80, 94, 95 These observations indicate that. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine cancer Chloroquine, Past and Present In the Pipeline, Chloroquine Is a Zinc Ionophore - PubMed Central PMC Ocular issue plaquenilHydroxychloroquine renal dosingChloroquine diphosphate autophagyLevaquin and hydroxychloroquineHydroxychloroquine sulphate tabletsrheumatoid arthritis Indeed, Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. This is why Chloroquine has become part of many clinical trials, in combination with chemotherapy and other form of cancer treatments. Chloroquine & Hydroxychloroquine supporting chemo.. Chloroquine and hydroxychloroquine for cancer therapy. The Chloroquine Story in Cancer Continues In the Pipeline. Jun 22, 2018 NETs promote hypercoagulability in murine PDA through stimulation of platelets and release of tissue factor. Chloroquine inhibits NETs and diminishes hypercoagulability. These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.