So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Chloroquine endocytosis How to take chloroquine Plaquenil and easy bruising Ok. so i tried plaquenil to see if it would help my dry eyes and mouth and maybe the progression although i dont have the RA symptoms yet. i tried 200mg 2 tablets-at once. so actually i took 400mg about 3 weeks ago and felt very fluish and my knees hurt very very bad. what dose do most of you start on. should i give plaquenil another try? SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Can you break plaquenil in half What REALLY Happens When You Fracture Your. - Men's Health, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine sulfate solubilityIs chloroquine still used to treat malaria So, it's possible that the plaquenil is helping, in that your immune system is calming down and moving back toward normal. As to whether it is reallying working for you - it's kinda hard to tell; if you stop taking it and you notice a difference, it's probably been helping. Anyone on Hydroxychloroquine plaquenil - Autoimmune.. What is the correct way to discontinue use of plaquenil?. Mycophenolate mofetil with Plaquenil Mayo Clinic Connect. Most time-released, long-acting, and combination drugs shouldn’t be split because it’s difficult to make sure that you’ll get the proper amount of the active ingredient in each half. Pills should only be split in half, not into smaller portions, such as thirds or quarters. The easiest pills to split are relatively flat round ones with a scored center, a slightly indented line that runs across the center of the pill. However, not every pill that has a scored center is meant to be split. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was.