Chloroquine mammalian cells

Discussion in 'Canadian Pharmaceuticals Online' started by ForsaPro, 27-Feb-2020.

  1. weec Well-Known Member

    Chloroquine mammalian cells


    [Reuters] that they evaluated the antiviral efficiency of seven drugs in vitro. Chloroquine, a widely used anti-malaria and autoimmune disease drug, has been known to block virus infections by changing the acidity and basicity value inside the cell and interfering with receptors of SARS coronavirus.

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    Chloroquine significantly inhibits Zika virus infection in multiple mammalian cell lines. Chloroquine protects against Zika virus infection in immunocompromised SCID Beige adult mice and neonatal mice. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. To mammalian lysosomes. Thus, if pH- mediated trapping were the only mech- anism of uptake, then the drug should be concentrated to a similar degree by mammalian cells. Furthermore, the fact that chloroquine is positively charged at physiological pH argues that the mol- ecule is not likely to diffuse freely across

    Vero E6 cells, derived from the kidney of an African green monkey, are one of the commonly used mammalian cell lines in microbiology and molecular and cell biology research. In the latest study, chloroquine shows an antiviral effect at both the entry and post-entry stages of the novel coronavirus infection in Vero E6 cells.

    Chloroquine mammalian cells

    Hydroxychloroquine is much less active than chloroquine., Chloroquine - Wikipedia

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  5. Chloroquine has a high affinity for tissues of the parasite and is concentrated in its cytoplasm. As a weak base, it increases the pH of the intracellular lysosome and endosome. A more acidic medium in these organelles is needed for the parasite to affect mammalian cells. As a result, chloroquine inhibits growth and development of parasites.

    • Chloroquine - an overview ScienceDirect Topics.
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    Chloroquine is an inhibitor of the lysosomal degradation of the DNA which is taken up by the cells, so as leelee said, transfection should have been successful, albeit at a slightly lower level than if you would have added the chloroquine. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.

     
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  7. LaSStiK Well-Known Member

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  8. DIOM Well-Known Member

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    Hydroxychloroquine Side Effects, Dosage, Uses, and More