At first, the surges began in the evening, with pounding heartbeat, shakiness, breaking out in sweat, anxious feeling, and the need to have a bowel movement. Sometimes this would continue until I had fully evacuated my bowel, waking me again and again for up to four hours, and then would subside. Plaquenil to treat fibromyalgia Can i take zyrtec with plaquenil Chloroquine generic brand Hypertension High Blood Pressure Fifty percent of people with lupus experience hypertension high blood pressure, which is defined as a blood pressure of greater than 140/90 mmHg. In addition, many more lupus patients have blood pressures greater than the normal 120/80 mmHg limit. Summary High blood pressure is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. blood tests. Hidden costs. I lost my appetite, could barely eat due to nausea (no vomiting), began losing weight, diarrhea. I was already taking Atenolol (beta blocker) for many years for intermittent palpitations from mitral valve prolapse and migraines, so he increased my dosage to twice a day to help with the symptoms. Then, the frequency continued until these surges were almost constant. Plaquenil and blood pressure Can I have high blood pressure from Plaquenil?, Will you have High blood pressure with Plaquenil - eHealthMe Plaquenil mechanism of action Feb 19, 2020 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Common and Rare Side Effects for Plaquenil Oral. Re Lupus and blood pressure spikes when sleeping. hey i forgot to tell you also that the bio- identical hormone therapists checks my hormones every 3 mths nad they found that the cortisal level are extreme high in the in evening early morning we are suppost to be leveling off to go to sleep but the blood tests cannot detect this as well. Hydroxychloroquine HCQ, a common anti-rheumatic medication, can be cardiotoxic and cause systolic or diastolic heart failure HF. A 65 year old man presented with acute decompensated HF. He had a history of rheumatoid arthritis, and had been treated with hydroxychloroquine for the last 8 years. I only experienced side effects for the first month I was on it. Now I dont have any side effects and I take 400mg a day. I only worry that you being off of plaquenil completely for 2 weeks is going to back fire and start your inflamation again which will take a while for the plaquenil to kick back in.