I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. I need an eye exam for plaquenil retinal function Hydroxychloroquine and antacids Flomax and plaquenil Chloroquine for malaria treatment Answer. Both drugs are well tolerated and useful in patients with lupus associated arthritis. Its difficult to comment directly on your situation. In general, most rheumatologists including myself use Plaquenil before MTX for lupus arthritis. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Interaction between Methotrexate and Plaquenil There is no known interaction between Methotrexate and Plaquenil in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Plaquenil vs methotrexate Arthritis Board Index plaquenil vs methotrexate, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil for mrsaCan plaquenil cause edema Check the latest outcomes from 50,877 Plaquenil users, or browse all drugs. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Check the latest outcomes from 339,740 Methotrexate users, or browse all drugs. Plaquenil vs. Methotrexate side effect and effectiveness.. Compare Methotrexate vs Plaquenil for RA - Comprehensive.. Methotrexate and plaquenil -. May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients Lisa Schapink. Department of Rheumatology, Sint Maartenskliniek, the Netherlands. Department of Rheumatology, Radboudumc, Nijmegen, the They are different treatments. Plaquenil is a maintenance drug in order to help prevent organ damage. Methotrextate is usually given for RA. I was on both for 6 years. No issues except some minor stomach nausea and was given a med for that which helped.