Eighty-one (74.3%) of the 109 respondents, including two Asian and one white patients, recalled the past occurrence of regular (60%) or occasional (40%) pruritus under those conditions, and 15 black patients (13.8%) under active treatment were currently experiencing itching. The typical pruritic reaction following chloroquine administration was generalized, began after a latency of 11 ± 9 hours (mean ± SD of 15 acute reactions), increased to a moderately severe peak of intensity within 25 ± 12 hours, remained maximal for about 12 hours, and then gradually subsided completely 55 ± 21 hours after onset. Plaquenil retinal toxicity night vision Plaquenil and thinning outer nuclear layer of retina Plaquenil and weed A questionnaire survey was performed among 550 acutely febrile patients with malaria to determine whether pruritus accompanied chloroquine therapy when the drug was employed to suppress paroxysmal febrile attacks. Eighty-one 74.3% of the 109 respondents, including two Asian and one white. Chloroquine phosphate may cause an upset stomach. Take chloroquine phosphate with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use chloroquine phosphate exactly as directed. Do not use more or less of it or use it more often than prescribed by your. Substitutes and alternatives to chloroquine for uses like Malaria, Extraintestinal amebiasis and Lupus chloroquine Alternatives & Similar Drugs - Skip to full site navigation These results suggest that certain undetermined factors, present in febrile patients with malaria, predispose to 4-aminoquinoline-induced pruritus. Antihistamines were largely ineffective for the relief of pruritus. How chloroquine is related to itch Chloroquine Side Effects Common, Severe, Long Term -, Chloroquine MedlinePlus Drug Information Plaquenil 100mg tabletsOct plaquenilPlaquenil side effects dry skinWhat are some side effects of hydroxychloroquine Chloroquine CQ has been used to treat malaria, certain viral infections 1 and a number of autoimmune diseases including rheumatoid arthritis 2 and systemic lupus erythematosus 3. Chloroquine also induces itch in humans and scratching in mice 4, 5 via a histamine-independent pathway linked to activation of Mrgprs 6. Peripheral NMDA Receptor/NO System Blockage Inhibits Itch.. Chloroquine Alternatives & Similar Drugs -. How a new understanding of itch leads to better pain.. Several studies have suggested that there could be heredo-familial factors influencing chloroquine induced pruritus2,9,10. Study has shown that, 133 40.20% of 331 patients experienced itching to chloroquine and all those prone to itching to chloroquine did so after oral administration of the drug. The pain work led to an interest in itch, and Bautista has accumulated a variety of agents that stimulate the itch reflex, including the plant called cowhage Mucuna pruriens and the drug chloroquine, an antimalarial that often causes a hellish, all-over itch. In some African countries, up to 70 percent of the population develops itch from. Ing chronic pruritus. Translational models of non-histaminergic itch are required for the development of novel drugs. Chloroquine CQ is an antimalarial drug widely used in African patients. CQ induces general-ized pruritus as most common side effect and is a cause of treatment discontinuation.