Tamoxifen antidepressants

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  1. tonsa Well-Known Member

    Tamoxifen antidepressants


    Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 4, 2015 (Health Day News) -- Breast cancer survivors who take antidepressants while on the cancer drug tamoxifen are not at increased risk for a return of their cancer, a new study finds. Tamoxifen is widely used to reduce the risk of breast cancer returning. But it can cause unpleasant side effects, including hot flashes and depression. As a result, nearly half of the 2.4 million breast cancer survivors in the United States take antidepressants, the study authors said."Given that thousands of breast cancer survivors struggle with depression, sleep disturbance and other side effects while on tamoxifen, our study should help alleviate any concerns physicians have about prescribing antidepressants to their breast cancer patients to help improve their quality of life," Reina Haque, a research scientist at Kaiser Permanente Southern California, said in a Kaiser news release. Previous research suggested that antidepressants reduce the effectiveness of tamoxifen, so Haque's team conducted a study to determine if that was true. The study included nearly 16,900 early stage breast cancer survivors who took tamoxifen for an average of three years. During a 14-year follow-up, breast cancer returned in more than 17 percent of the women. Was developed to block estrogen and therefore stop that growth, to help treat, prevent, and stop the recurrence of most breast cancer. Breast cancer that is sensitive to estrogen is called “estrogen receptor-positive breast cancer.” For tamoxifen to do its job, it needs to be broken down in the body by a key protein known as CYP2D6. Unfortunately, many common medicines can block or slow down CYP2D6, and that would make tamoxifen less effective. Certain medications used to treat depression should be avoided by women taking tamoxifen. The antidepressants paroxetine (Paxil) and fluoxetine (Prozac) have been found to increase women’s risk of dying of cancer if they are taking tamoxifen. Women who are on these medications should talk to their doctors about switching to other medicines that don’t affect how tamoxifen works. If you are taking tamoxifen, talk to your doctor about any medications that you are taking (including over-the-counter products, such as cold and allergy medications) to be sure that they don’t interfere with tamoxifen.

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    Sep 30, 2016. Revisiting the drug interaction between tamoxifen and SSRI antidepressants. BMJ 2016; 354 doi https//doi.org/10.1136/bmj.i5309 Published. FRIDAY, Dec. 4, 2015 HealthDay News -- Breast cancer survivors who take antidepressants while on the cancer drug tamoxifen are not at increased risk for a return of their cancer, a new study. Some antidepressants are such strong inhibitors of CYP2D6 that women who take these drugs may not benefit from tamoxifen. Two papers suggest that three antidepressants — paroxetine Paxil, fluoxetine Prozac, and bupropion Wellbutrin — are most likely to inhibit CYP2D6 and interfere with tamoxifen treatment.

    Tamoxifen is a hormone therapy drug taken by many premenopausal women after completing their initial treatments for estrogen receptor positive breast cancer. To treat the side effects of tamoxifen (such as hot flashes) and to help with depression, doctors often prescribe antidepressants. Yet many antidepressants can interfere, or completely cancel out, the benefits of tamoxifen. Once a woman is finished with the primary treatment of breast cancer, with therapies such as surgery, chemotherapy, and radiation therapy, she may need to take tamoxifen. For women who have estrogen receptor positive tumors, hormone therapy can reduce the risk of the cancer coming back (recurrence) by around 50 percent. The choice of medication depends on menopausal status. If a woman is premenopausal, tamoxifen is usually the drug of choice. (For those who are postmenopausal, or who are premenopausal but have received ovarian suppression therapy, an aromatase inhibitor is usually used instead). Few topics in therapeutics are more vexing than drug interactions. They number in the thousands, involve confusing terminology, and are rarely supported by evidence stronger than case reports and volunteer studies.1 It’s not surprising, therefore, that experts disagree on which interactions are serious and which ones are not.2 And yet their importance is undeniable because they can cause serious morbidity or even death, despite epitomizing, in theory at least, avoidable drug related harm. Over the past decade, few drug interactions have been as controversial as those involving tamoxifen and selective serotonin reuptake inhibitor (SSRI) antidepressants,3 explored yet again by Donneyong and colleagues in a linked study (doi:10.1136/bmj.i5014).4 On its surface, the issue seems straightforward: as a prodrug, tamoxifen requires conversion to active metabolites, the most important of which is endoxifen. This process is influenced by cytochrome-P450 isoenzyme 2D6 (CYP2D6), an enzyme characterized by marked variability from person to person. Some SSRIs but not others inhibit CYP2D6, conceivably attenuating or even abolishing the benefits of tamoxifen. The importance of this potential interaction is amplified by three factors. First, tamoxifen is a monumental treatment, conferring dramatic reductions in breast cancer recurrence and associated mortality.5 Second, antidepressants are often co-prescribed with tamoxifen for extended periods,6 in part because depression often coexists with breast cancer and in part to offset vasomotor symptoms induced by tamoxifen.7 Third, and in contrast with most drug interactions, the consequences are delayed by years and manifest simply as treatment failure, undermining causal attribution at the patient level.

    Tamoxifen antidepressants

    Drugs to Avoid for Women Taking Tamoxifen - Stop Cancer Fund, Antidepressants With Tamoxifen Safe Study - WebMD

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  3. We investigated whether taking tamoxifen and antidepressants in particular, paroxetine concomitantly is associated with an increased risk of.

    • Tamoxifen and Antidepressant Drug Interaction Among a Cohort of..
    • Antidepressants and tamoxifen - Harvard Health.
    • Tamoxifen and Antidepressants Cancer Survivors Network.

    A study found that women taking the antidepressant Paxil chemical name paroxitene at the same time as the hormonal therapy medicine tamoxifen were more likely to die from breast cancer than women taking tamoxifen who never took Paxil. This result is similar to results from other research and. Background/Aims antidepressant-tamoxifen drug taken by many of tamoxifen with tamoxifen at the risk of. Endoxifen is a drug interactions between tamoxifen to manage their risk of. To treat the selective serotinin reuptake inhibitors prozac and say you will get used for breast. The issue of tamoxifen inhibition by antidepressants first surfaced in 1999, when Vered Stearns, M. D. now at the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine in Baltimore, was treating a woman with severe hot flashes from tamoxifen.

     
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