Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Chloroquine sensitive areas Chloroquine-treated case of plasmodium vivax Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes. Chloroquine further supports this mechanism by blocking utilisation of extracellular cholesterol by neutralising the lysosome, thereby rendering cancer cells dependent on the biosynthesis pathway to maintain cellular and lysosomal membrane cholesterol homeostasis and lysosomal membrane integrity. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Lysosome chloroquine The lysosomal inhibitor, chloroquine, increases cell surface., The Chloroquine Story in Cancer Continues In the Pipeline Can i take tylenol with hydroxychloroquinePlaquenil 20 mgPlaquenil and imuran heat and sun side effectsHydroxychloroquine hyperpigmentationCan you take vitamins with plaquenil Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Chloroquine Uses, Side Effects & Warnings -. Chloroquine treatment of ARPE-19 cells leads to lysosome.. Chloroquine inhibits autophagic flux by decreasing.. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.