It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine trade name Plaquenil chronic fatigue syndrome Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. What are some of the side effects of plaquenil Plaquenil hydroxychloroquine Basics, Side Effects & Reviews., Plaquenil Side Effects on Your Eyes and Vision Plaquenil to treat skin rashPlaquenil and double visionVulvodynia improvement with plaquenil Many doctors disagree about the effects of plaquenil on the arthritis. It does help in about 60 % of the cases of arthritis by significantly reducing the pain. However, about 20 – 30 percent of people stop using it because of the side effects. Side effects include digestive problems, skin rash and disorders of skin pigmentation. Side effects of Plaquenil Other Drugs discussions.. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil oral Reviews and User Ratings Effectiveness, Ease.. May 07, 2012 Saturday was a week since I stopped taking Plaquenil, aka Hydroxychloroquine, per my doctor's instructions, and I think I am going through some form of withdrawal. I took the drug as a treatment for sarcoidosis and one of the side effects is a reduction in white blood cells, which is what has happened to me. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.