The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Plaquenil chronic urticaria Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks For RA patients, methotrexate is used in a completely different way.” At these extremely lower doses, methotrexate has a completely different effect on the body. It is a disease-modifying agent that reduces inflammation. “I like to say it’s the difference between swimming in a pool and drinking a glass of water. Hi Everyone, I went to my Rheumatologist last week. She is giving me and my gastro. dr. a choice between Plaquenil and Methotrexate. One affects your eyes more and one affects your liver more. That is what my dr. said. So, what do yall know about the side effects of both and the benefits of both? I would appreciate any I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Compare Plaquenil vs Chloroquine -, Common Questions About Taking Methotrexate for Rheumatoid. Macular degeneration plaquenilCpt code plaquenil screeningPlaquenil pill sjogren'sPlaquenil adverse reactions Between groups per-protocol analysis after intervention Mean SD LPPAI in methotrexate group at baseline, 4.63 1.83, was significantly higher than that in hydroxychloroquine group, 3.46 0.94, P = 0.04. reveals LPPAI difference between the two groups at Clinical efficacy and safety of methotrexate versus.. Which would you pick and why? - Plaquenil or Methotrexate. Evaluation of efficacy of combination of methotrexate and.. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. more Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis. After an inadequate response to methotrexate, several treatments were statistically superior to oral methotrexate for ACR50 response triple therapy, methotrexate plus hydroxychloroquine, methotrexate plus leflunomide, methotrexate plus intramuscular gold, methotrexate plus most biologics, and methotrexate plus tofacitinib. What if there was a difference between methotrexate injection and oral methotrexate in terms of effectiveness and risk of side effects? According to results from the first clinical trial to systematically investigate the optimal administration of methotrexate in patients with active rheumatoid arthritis, published in the January 2008 issue of Arthritis & Rheumatism, methotrexate injection.