Drug of choice for chloroquine resistant malaria

Discussion in 'Chloroquine Drug' started by Gromoff, 15-Mar-2020.

  1. B0gdana Moderator

    Drug of choice for chloroquine resistant malaria

    According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance.

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    Artemisinin has been a very potent and effective antimalarial drug, especially when used in combination with other malaria medicines. 3 Combining an artemisinin drug with a partner drug that has a longer half-life was found to improve the efficacy of the artemisinin. Insulin and other antidiabetic drugs As Chloroquine may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or other antidiabetic drugs may be required. One clinical report has suggested that chlorpheniramine in combination with chloroquine may give improved results over chloroquine alone in African children with uncomplicated malaria from chloroquine-resistant P. falciparum. This combination remains in the exploration stage

    These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine).

    Drug of choice for chloroquine resistant malaria

    Chapter 98 Antiprotozoal Drugs I Antimalarial Agents., Chloroquine - FDA prescribing information, side effects and uses

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  5. Atovaquone-Proguanil FDA-approved in 2000, atovaquone-proguanil Malarone is a combination drug that is used for the prevention and treatment of uncomplicated chloroquine-resistant P. falciparum malaria.

    • Malaria Treatment and Prevention - U. S. Pharmacist.
    • Chloroquine-Resistant Malaria The Journal of Infectious Diseases..
    • Drug resistance in malaria - World Health Organization.

    The treatment regimens for chloroquine-resistant P. vivax infections are quinine sulfate plus doxycycline or tetracycline, or, atovaquone-proguanil, or artemether-lumefantrine, or mefloquine. These treatment options are equally recommended. Used as a drug of choice to treat chloroquine resistant malaria. Resistance to SP was first described from the Thai-Cambodian border in 1960s 28. Since then SP re-sistance has been reported from large parts of South-east Asia, southern China and Amazon basin9,29,30. Low degree of resistance is found in Pacific Coast of ANSWER There are a number of medicines used to treat malaria. Traditionally, chloroquine has been the first line drug of choice for uncomplicated, non-resistant malaria. However, several types of malaria, and most notably Plasmodium falciparum, the most severe and deadly kind, has become resistant to chloroquine in many places.

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    Understanding Steady State Pharmacokinetics – Certara Nov 25, 2013 The rule of thumb is that steady state will be achieved after 5 half-lives 97% of steady state achieved.” Is it related to dose regime as well? Such as, if the half life is 3 hours, but the dose interval is 24 hrs.

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  8. Innes Moderator

    History of antimalarials Medicines for Malaria Venture Artemisinin and other artemether-group drugs have been the main line of defense against drug resistant malaria in many parts of South-East Asia. Artemisinin has been a very potent and effective antimalarial drug, especially when used in combination with other malaria medicines. 3 Combining an artemisinin drug with a partner drug that has a.

    Epidemiology, Drug Resistance, and Pathophysiology of.