Flying saucer sign plaquenil

Discussion in 'Chloroquine Drug' started by Semka, 17-Mar-2020.

  1. Sergeinn XenForo Moderator

    Flying saucer sign plaquenil


    To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation.

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    Patient 2 was found to have a completely normal fundus examination. Fluorescein angiography shows parafoveal hyperfluorescence, and autofluorescence shows a minimal decrease in signal in the same region. In both patients the SD-OCT shows disruption of the ellipsoid zone in parafoveal region flying saucer sign. Oct 21, 2010 All five patients did have abnormalities on HVF 10-2 perimetry, ranging from paracentral to dense scotomas. In the five patients with SD OCT abnormalities, 3 had signs of early HCQ retinopathy while 2 had advanced changes. The “flying saucersign was present in all three of the five patients who presented with early HCQ retinopathy. Late signs decreased visual acuity, bull's eye maculopathy, paracentral hyperfluorescence on fluorescein angiography, thinning of the paracentral outer retina on time-domain OCT, 24-2 HVF paracentral VF defects, decreased signal on full-field ERG.

    Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center.

    Flying saucer sign plaquenil

    Flying saucer drone, Spectral domain optical coherence. - PubMed Central PMC

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  4. SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucersign, and peripapillary nerve fiber layer thinning 12–14. Few reports have examined progression of changes in SD-OCT appearance after drug cessation.

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    Mild paracentral scotoma is usually the earliest clinical sign of toxicity. Presents as a subjective complaint in a perceptive patient, or on formal visual field test. Most common early complaint is paracentral scotoma or difficulty with reading.3 Transmission defect on FA corresponds with pigment mottling Patient 2 was found to have a completely normal fundus examination. Fluorescein angiography shows parafoveal hyperfluorescence, and autofluorescence shows a minimal decrease in signal in the same region. In both patients the SD-OCT shows disruption of the ellipsoid zone in parafoveal region “flying saucersign. Figure 1 The flying saucer sign representing compromise of the perifoveal retinal tissue with maintenance of the foveal retinal tissue. From Chen E, Brown DM, Benz MS, et al. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucersign.

     
  5. alex_popov Moderator

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Plaquenil & Wine - Sjogren's World Plaquenil Warnings and Precautions Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  6. Dark_Guard Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Can someone tell me exactly what plaquenil does. - HealthBoards Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine.
     
  7. anhydrous New Member

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Stop taking.

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  8. serqo User

    Plaquenil and Hemolytic Anemia - Sjogren's World Have any of you who have taken Plaquenil developed Hemolytic Anemia? I just got back from the NIH in which I participate in an MGUS Natural History Study.my preliminary bloodwork indicated high Reticulocyte Percentage for the first time.

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