It is very famous (for its effectiveness) rather infamous (for its characteristic bitter taste), I still remember during my childhood back in India, elders used to threaten kids that if they won’t sleep in bed equipped with mosquito nets, they would have to eat chloroquine, and all kids out of fear for chloroquine rather malaria itself, would immediately agree to go to bed under the net (which they otherwise did not like normally). Anyways, in last few decades because of emerging chloroquine-resistant malaria parasites, chloroquine was almost forgotten and researchers started to look for other more effective and less toxic drugs to treat and prevent malaria. Aao plaquenil guidelines Plaquenil maculopathy monitoring The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line A2780. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Maycotte P1, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. Autophagy (from Greek auto-oneself, phagy-to eat) is a process of self-cannibalization which is dependent on the presence of autophagosomes, autolysosomes, as well as an intact nucleus in the cell. It is only last couple of years that chloroquine got sudden attention especially among biologists when cancer biologists noticed its role as an inhibitor of autophagy. Chloroquine ovarian cancer Abstract 3211 Inhibition of autophagy potentiates., Chloroquine Sigma-Aldrich Plaquenil pregnancy sjogren& 39Does hydroxychloroquine cause cirrhosis Nov 15, 2015 The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line A2780. Chloroquine enhanced zinc uptake by A2780 cells in a concentration-dependent manner, as assayed using a fluorescent zinc probe. Chloroquine & Hydroxychloroquine supporting chemo.. The Chloroquine Story in Cancer Continues In the Pipeline. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Nov 04, 2015 Chloroquine CQ, the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. Qunine and Chloroquine Interestingly, it has been recently reported in the Nature magazine that the antimalaria drug Quinine that is also known to have anti cancer actions its derivative chloroquine has strong anti cancer effects as well interferes with serotonin biosynthesis and action Ref. I just checked some older studies and it. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects.