Chloroquine lysosomal membrane permeabilization

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  1. OlgaStarXXXL Moderator

    Chloroquine lysosomal membrane permeabilization


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    Normal lysosomal degradation function is crucial to maintain cellular homeostasis and enable cell survival in the physiological state. Due to its high hydrolase content, lysosomes are potentially harmful to the cell when damage occurs to the lysosomal membrane to induce lysosomal membrane permeabilization LMP. Transcription factor EB TFEB is a master transcriptional regulator playing a key role in lysosomal biogenesis, autophagy and lysosomal exocytosis. TFEB activity is inhibited following its phosphorylation by mammalian target of rapamycin complex 1 mTORC1 on the surface of the lysosome. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future.

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    Chloroquine lysosomal membrane permeabilization

    Lysosomal Membrane Permeabilization Induces Cell Death in., Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization.

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  7. Sunitinib is a lysosomotropic drug, thus accumulates in lysosomes, leading to their destabilization and to lysosomal membrane permeabilization LMP, which in turn can lead to cell death. Autophagy might be activated for clearance of damaged lysosomes, thus promote survival and act as a mechanism of resistance.

    • Abstract 3159 Lysosomal membrane permeabilization as..
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    Chloroquine is a lysosomotropic agent that triggers destabilization of the lysosomal membrane in various tumor cells. In one study chloroquine was used to restore sensitivity to cisplatin in refractory non-small-cell lung cancer cells 82. Furthermore, it has been reported that chloroquine causes direct lysosomal membrane permeabilization, with the subsequent release of lysosomal products i.e. cathepsins from the lysosomal lumen into the cytosol. Chloroquine triggers lysosomal membrane permeabilization in A549cisR cells, promoting the release of lysosomal cathepsins into the cytosol. A549Pt A and A549cisR B cells were loaded with FITC.

     
  8. Gamayun XenForo Moderator

    I don't know if anyone can help as this isn't technically lupus related. Why Your RA Went Into Remission, but Relapsed Arthritis. PLAQUENIL Side Effects, Reviews by Patients - Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  9. GeorgyS Well-Known Member

    Hi Everyone, I went to my Rheumatologist last week. I take these for the arthritis associated with my lupus. If you have any particular questions, I would be happy to answer them. The chance of damage to the eyes with plaquenil is extremely slim. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. Methotrexate and Coronavirus Apologies if this. - LUPUS UK Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs RA and Hydroxychloroquine How Effective is it for Rheumatoid Arthritis.
     
  10. Flambaster Well-Known Member

    Chloroquine Indications, Side Effects, Warnings - What are some other side effects of Chloroquine? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away Belly pain. Stomach cramps. Not hungry.

    Side Effects of Chloroquine and Primaquine and Symptom.
     
  11. Oleg Cat New Member

    Plaquenil and loss of appetite - Lupus - MedHelp Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process.

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