It is highly effective against the gametocytes of all plasmodia and thereby prevents spread of the disease to the mosquito from the patient. It is also effective against the dormant tissue forms of P. ovale malaria, and thereby offers radical cure and prevents relapses. Chloroquine hemolytic transfusion reaction Chloroquine dosage for lupus Primaquine phosphate is 8-4-amino-1-methylbutylamino-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of primaquine phosphate equivalent to 15 mg of primaquine base. The dosage is customarily expressed in terms of the base. Approximately 90% of lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline. The plasma binding of lidocaine is dependent on drug concentration, and the fraction bound decreases with increasing concentration. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Absorption, fate and excretion: It is well absorbed after oral administration and rapidly metabolised. The metabolites of primaquine have oxidative properties and can cause hemolysis in susceptible patients. It has insignificant activity against the asexual blood forms of the parasite and therefore it is always used in conjunction with a blood schizonticide and never as a single agent. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Chloroquine-urinaquine Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P., LIDOCAINE OINTMENT USP, 5% Retinal thinning in plaquenil toxicityOct test for plaquenilPlaquenil photo Primaquine can effective in treating malarial infections, but there are many precautions while taking primaquine. Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people. Compare Primaquine vs Chloroquine -. Chloroquine Uses, Side Effects, Dosage & Interactions. Chloroquine and primaquine combining old drugs as a new weapon against.. Primaquine phosphate is an 8-amino-quinoline compound which eliminates tissue exoerythrocytic infection. Thereby, it prevents the development of the blood erythrocytic forms of the parasite which are responsible for relapses in vivax malaria. Primaquine phosphate is also active against gametocytes of Plasmodium falciparum. INDICATIONS AND USAGE Methods and findings. Patients with normal glucose-6-phosphate dehydrogenase status with symptomatic P.vivax mono-infection were enrolled and randomly assigned to receive either chloroquine CQ or artemether-lumefantrine AL, alone or in combination with 14 d of semi-supervised primaquine PQ 3.5 mg/kg total. Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation.