Mechanism of chloroquine resistance

Discussion in 'Generic & Brand Canadian Pharmacy' started by hoseo, 23-Feb-2020.

  1. WiseFire Guest

    Mechanism of chloroquine resistance


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of chloroquine resistance

    Drug resistance in malaria - World Health Organization, Chloroquine - Wikipedia

  2. Reviews on hydroxychloroquine
  3. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Drug Resistance in the Malaria-Endemic World.
    • Chloroquine – howMed.

    The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance Science Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than. Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM

     
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  6. PcuX Well-Known Member

    DailyMed - CHLOROQUINE PHOSPHATE tablet Chloroquine phosphate is an antimalarial and amebicidal drug. Chemically, it is 7-chloro-4-4- diethylamino-1-methylbutylamino quinoline phosphate 12 and has the following structural formula Each tablet contains 250 mg of chloroquine phosphate USP, equivalent to 150 mg chloroquine base.

    Chloroquine Indications, Side Effects, Warnings -