Metabolic fate of chloroquine

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by Anastheziya, 08-Mar-2020.

  1. a21 User

    Metabolic fate of chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Tation suggests a systemic cause, such as a metabolic disorder or drug toxicity. Antimalarial agents, such as chloroquine diphosphate and hydroxychloroquine sul-fate, are administered for treatment of several dermato-logic and rheumatologic disorders, and they are known to cause hyperpigmentation of the oral mucosa 9,15. Since amino acids can not be stored in the body for later use, any amino acid not required for immediate biosynthetic needs is deaminated and the carbon skeleton is used as metabolic fuel 10-20 % in normal conditions or converted into fatty acids via acetyl CoA. The main products of the catabolism of the carbon skeleton of the amino acids are pyruvate, oxalacetate, alpha-ketoglutarate. Combination ADI-PEG20 and chloroquine causes synthetic lethality. Metabolic stress caused by arginine deprivation can trigger a cell survival mechanism either by inducing an acute response in autophagy followed by the rapid re-expression of ASS1 or cell death if ASS1 is not reactivated.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Metabolic fate of chloroquine

    Aralen chloroquine Malaria Drug Side Effects & Dosage, Metabolism of the carbon skeletons of amino acids

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  7. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Metabolic and therapeutic stresses can simultaneously provoke a series of adaptive responses and suicide signals in cancer cells. The sum of these programmed adaptation and death signals determines the fate of the cell cell death or cell survival. Gut-Mediated Bioactivation of Polyphenols in the Human Superorganism. The human colon harbors a highly complex microbial ecosystem, at concentrations of 10 12 microorganisms per gram of gut content. The gut microbiota composition of each individual is unique and is influenced through a legacy acquired at birth, genotype and physiological status of the host, diet, and lifestyle 17, 18. Metabolic fate of pancreas-derived cholesterol esterase in intestine An in vitro study using Caco-2 cells. Chloroquine had no effect on the degradation or re-secretion of cholesterol esterase.

     
  8. Lexikon User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Indications, Side Effects, Warnings. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Is Chloroquine a Cure for Coronavirus? Scientists Say Maybe.
     
  9. i-sqautter Moderator

    Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it.

    Taking Plaquenil for Rheumatoid Arthritis