Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Does plaquenil affect blood pressure Plaquenil dreams Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hi Wimpy12 - I have PsA and my first biologic was Enbrel, along with Plaquenil. My doctor also tried adding in MTX, Arava, and several other DMARDS but my liver enzymes would rise. So used Enbrel alone and it worked great, have since switched to Cimzia and it is working good too. Before using Plaquenil, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase G-6-PD deficiency. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil and liver enzymes Plaquenil -, Plaquenil and Enbrel - Arthritis - Inspire Can plaquenil cause edema Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal. Plaquenil and elevated liver enzymes? - Sjogren's World. Plaquenil Uses, Dosage & Side Effects -. Plaquenil And Mood Swings? - Sclero Forums MAIN - Sclero Forums. Liver enzyme abnormality was defined as a 10-fold or greater increase in aspartate aminotransferase and alanine aminotransferase. Acute toxic hepatitis was diagnosed, which rapidly returned to normal after cessation of the suspected causative medication, hydroxychloroquine, and subsequent administration of mycophenolate mofetil. Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. Increased serum level of liver enzymes is a common finding in patients with systemic lupus erythematosus SLE. Hepatotoxic drugs, viral hepatitis and fatty liver are thought to be the main causes of hepatic lesion in these patients.