Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Hydroxychloroquine accidental drug overdose Plaquenil bleeding Usp grade chloroquine Chloroquine dreams I don't think so. From what I read, it is likely because CQ and HCQ increase endosomal pH, which disrupts action of several enzymes required for viral replication. This action presumedly also inhibits the production of some inflammatory enzymes, thus why it is effective in some autoimmune disorders. In these patients, high doses of hydroxychloroquine may trigger liver damage. 9, 10, 17 From the community “I was on Plaquenil for 5 1/2 yrs with no liver problems but had to stop it because it had started to affect my retinas.” - Inspire member “I take 200 mg of Plaquenil a day. I was told it can take months to help and it did. That I had high liver enzymes. All I want to do is sleep, I also hurt in my stomach most of the time. My urine is very dark I don t get hungry. I was on Nexuim but stopped. Can plaquenil cause liver damage Chronic liver damage causes Liver damage caused by iud. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil increase liver enzymes Plaquenil and Enbrel - Arthritis - Inspire, Hydroxychloroquine Plaquenil Success, Reviews and Side. Chloroquine and ciprofloxacinDoes plaquenil show up in the bloodNursing interventions for hydroxychloroquineChloroquine phosphate medicineCan plaquenil cause erectile dysfunction Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Can plaquenil cause liver damage - Doctor answers on.. Hydroxychloroquine-induced toxic hepatitis in a patient.. I have recently started taking plaquenil foe RA. My doctor called and said their was a slight change in my liver numbers. He said it is nothing to worry about. I was wondering does plaquenil affect your liver? If any of you experienced this please let me know. Thank-you, JK An increase in cholesterol and liver enzymes is also a risk. Corticosteroids. Corticosteroid drugs help fight inflammation and depress your immune response. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.