Chloroquine interfere nucleic acid biosynthesis

Discussion in 'International Pharmacy' started by gibz, 27-Feb-2020.

  1. Pan Russian XenForo Moderator

    Chloroquine interfere nucleic acid biosynthesis


    Despite drastic containment measures, the spread of this virus is ongoing. SARS-Co V-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans.

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    Chloroquine can inhibit a pre-entry step of the viral cycle by interfering with viral particles binding to their cellular cell surface receptor. Chloroquine was shown to inhibit quinone reductase 2, a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic. Feb 17, 2020 The mechanism is that the chloroquine can interfere with the biosynthesis of nucleic acids, thus preventing DNA replication and RNA transcription. Inhibition of Nucleic Acid Synthesis by Antibiotics BioFiles 2006, 1.4, 7. Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II DNA gyrase, an enzyme involved in DNA replication.

    In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-Co V-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-Co V-1. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease.

    Chloroquine interfere nucleic acid biosynthesis

    New Discovery Reveals Africa's Anti-Malaria Drug., Antimalarial drug proves effective on COVID-19 patients - CGTN

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  4. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It may also interfere with the biosynthesis of nucleic acids.

    • Chloroquine.
    • Inhibition of Nucleic Acid Synthesis by Antibiotics Sigma..
    • Antimetabolites That Interfere with Nucleic Acid Biosynthesis..

    Availability. Hydrochloride 250 mg, 500 mg tablets; 5 mg, 50 mg/mL ampule Phosphate 250 mg, 500 mg tablets Actions. Antimalarial activity is believed to be based on its ability to form complexes with DNA of parasite, thereby inhibiting replication and transcription to RNA and nucleic acid synthesis. Feb 27, 2015 For nucleic acid biosynthesis, which is energetically costly, the nucleotide synthesis consumes 0.5–9 pmol exogenous carbon, which is comparable in number to the ATP hydrolysis. Thus, to make nucleic acids for cell proliferation purposes, cells have to upregulate both energy metabolism and the nucleotide biosynthetic pathways. Nucleic Acid Synthesis Nucleic acids are synthesized from triphosphate nucleotide precursors by DNA or RNA polymerases using DNA as a monophosphorylated nucleotides are linked together by phosphodiester bonds between the 3′ hydroxyl of ribose or deoxyribose, and the 5′ hydroxyl group of the next sugar in a 5′ to 3′ direction Fig. 14.

     
  5. Jesse James Well-Known Member

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria Aralen chloroquine Malaria Drug Side Effects & Dosage Medicines for the Prevention of Malaria While Traveling.
     
  6. Yola User

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health. Malaria in humans is caused by protozoan parasites of the genus Plasmodium Plasmodium falciparum, P. vivax, P. ovale, or P. malariae. In addition, P. knowlesi, a parasite of Old World Eastern Hemisphere monkeys, has been documented as a cause of human infections and some deaths in Southeast Asia.

    Chloroquine-Resistant Falciparum Malaria - How is.
     
  7. Basil555 XenForo Moderator

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