Chloroquine target cycle

Discussion in 'International Pharmacy' started by Hitter, 29-Feb-2020.

  1. ciper Guest

    Chloroquine target cycle


    However, there are growing problems with drug resistance that are posing a threat to the global fight against malaria. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body.

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    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Antimalarial drugs are used for the treatment and prevention of malaria infection. Most antimalarial drugs target the erythrocytic stage of malaria infection, which is the phase of infection that causes symptomatic illness. The extent of preerythrocytic hepatic stage activity for most antimalarial drugs is not well characterized. Chloroquine has a high affinity for tissues of the parasite and is concentrated in its cytoplasm. As a weak base, it increases the pH of the intracellular lysosome and endosome. A more acidic medium in these organelles is needed for the parasite to affect mammalian cells. As a result, chloroquine inhibits growth and development of parasites.

    Malaria is common in areas such as Africa, South America, and Southern Asia. Parasites that cause malaria typically enter the body through the bite of a mosquito.

    Chloroquine target cycle

    On the Mechanism of Chloroquine Resistance in Plasmodium., UpToDate

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  6. Different drugs target different features of the parasite’s biology and life cycle. For example, chloroquine targets the blood stages of the life cycle whilst primaquine removes the dormant liver stages. Because of this, drugs are often used in combination with each other to make sure the malaria parasite is removed from all areas of the body.

    • How is malaria treated and prevented? Facts.
    • Chloroquine - an overview ScienceDirect Topics.
    • Medicines for the Prevention of Malaria While Traveling..

    Feb 21, 2012 The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium A Comparative Study with Human and Rodent Parasites Michael Delves, 1 David Plouffe, 2 Christian Scheurer, 3, 4 Stephan Meister, 5 Sergio Wittlin, 3, 4 Elizabeth A. Winzeler, 2, 5 Robert E. Sinden, 1 and Didier Leroy 6, * Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. After the bioinformatics and survival analysis, we investigated whether increased ING1 induced cell cycle arrest in vitro. Then, the cell cycle distribution was assessed after 48 h of treatment with 0, 200, and 400 μM NTZ.

     
  7. Sergeich Well-Known Member

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