Just google does low dose naltrexone cause a herxheimer's reaction and I am sure you will find a lot of info. Did you have your med compounded from pure naltrexone powder or from ground up 50 mg Revia/generic equivalent? Here is how it applies to AP https://en.wikipedia.org/wiki/Type_III_hypersensitivity https://chronicillnessrecovery.org/index.php? Hi, Boise CGM- Can you please describe the "awful"? Happy to help if you can provide a few key details. What happens when you drink red wine on hydroxychloroquine Splitting hydroxychloroquine Feb 25, 2020 Anyone have any “herx” like this or been prescribe Plaquenil? I just want to feel better and feel like I’ve been worse. Psychologically I tell myself I know it’s going to bye bad before better, but other days I want to quit and can’t wrap my head around this. I appreciate anyone’s feedback or guidance through this. Oct 12, 2009 I feel so much better and fingers crossed, this continues. I do know some people take longer than others but i think i was in such a bad way before that i noticed the difference straight away. Some things have got worse, numbness, burning nerve issues etc but i guess it doesnt help with those type of issues. good luck annie From SilverColloids. The Herxheimer Reaction is a short-term from days to a few weeks detoxification reaction in the body. As the body detoxifies, it is not uncommon to experience flu-like symptoms including headache, joint and muscle pain, body aches, sore throat, general malaise, sweating, chills, nausea or other symptoms. He's excellent, open-minded, and in my opinion quite brilliant - and had the following comment when I asked him about LDN in an email. Kk I've quoted my scleroderma specialist on LDN here before, but will copy and paste it again. Will i feel worse before i feel better on plaquenil How long until Hydroxychloroquine takes effect - LUPUS UK, Plaquenil - How long to take effect? Stopped plaquenil now symptoms have returned Hello friends, I take my Plaquenil in the morning with breakfast. I feel very shaky, dizzy and just off all day. Does anyone take it at night? Will it keep me up? Why do I have to take it in the morning. Can I take Plaquenil at night? - Sarcoidosis - Inspire. Feeling worse before feeling better - The Best Years in Life. User Reviews for Hydroxychloroquine to treat. -. Plaquenil hydroxychloroquine for Systemic Lupus Erythematosus "I've been taking Plaquenil for 6 days now and I already notice a difference in my SLE. I almost feel normal. Before I struggled with fatigue and pain. Since its a mild stimulant it helps with my energy and my body is feeling so much better. Thanks for the replies,yep,self-induced flare,I think. I couldn't help being a numpty because I felt so good blush I just wondered if Plaquenil made you feel worse rather than better at the start like antibiotics can sometimes. It might be a bit of heartburn or gastritis. Make sure though to wait 2 hrs before and 2hrs after taking the plaquenil to take an antacid. Watch that sun. I find I feel worse when I've had too much of it. I'm prone to itching like crazy after too much sun. Are you using a broad spectrum sunscreen and UV protective clothing hat too?