Tamoxifen safety

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  1. gem_audience Guest

    Tamoxifen safety


    Tamoxifen citrate is also being studied in the treatment of other types of cancer. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. Medline Plus Information on Tamoxifen Citrate - A lay language summary of important information about this drug that may include the following: Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied. Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival Hormone Therapy for Breast Cancer Exemestane Following Tamoxifen Reduces Breast Cancer Recurrences and Prolongs Survival Study Confirms Letrozole Prevents More Breast Cancer Recurrences Than Tamoxifen Long-Term Data from 20 Trials Confirm Tamoxifen’s Long-Lasting Benefit Tool Weighs Benefits, Risks of Raloxifene or Tamoxifen to Prevent Breast Cancer Five Years of Tamoxifen Continues to Benefit Women 15 Years after Treatment Targeted Cancer Therapies Find Clinical Trials for Tamoxifen Citrate - Check for trials from NCI's list of cancer clinical trials now accepting patients. Important: The drug information on this page is meant to be educational. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. In 2006, the large STAR clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up, although the difference was not statistically significant, there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women taking tamoxifen. Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic–pituitary–gonadal axis (HPG axis) via ER antagonism and thereby increasing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and increasing testicular testosterone production. It is taken as a preventative measure in small doses, or used at the onset of any symptoms such as nipple soreness or sensitivity. Other drugs are taken for similar purposes such as clomifene and the anti-aromatase drugs which are used in order to try to avoid the hormone-related adverse effects. Occasionally tamoxifen is used in treatment of the rare conditions of retroperitoneal fibrosis A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone used to treat breast cancer significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects. Some cases of lower-limb lymphedema have been associated with the use of tamoxifen, due to the blood clots and deep vein thrombosis (DVT) that can be caused by this medication. Resolution of the blood clots or DVT is needed before lymphedema treatment can be initiated.

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    Revision 08/19/2018 Page 6 of 6 Tamoxifen SAFETY DATA SHEET Supersedes Revision 06/13/2014 Section 16. Other Information Additional Information About No data. Jan 5, 2014. Tamoxifen is a medication known as a selective estrogen receptor. This study supports soy's safety for women with a history of breast cancer. Ann Oncol. 2007 Sep;18 Suppl 8viii26-35. Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant therapy of hormone-responsive early breast.

    Tamoxifen has rarely caused very serious (possibly fatal) strokes, blood clots in the lungs/legs, and cancer of the uterus. If you are taking tamoxifen to reduce the risk of breast cancer, or if your cancer is limited to the milk ducts (ductal carcinoma in situ-DCIS), then discuss the benefits and risks of taking this medication with your doctor. However, if you are taking tamoxifen to treat breast cancer, then the benefits of taking tamoxifen are greater than the risks of side effects. Get medical help right away if you develop symptoms of a stroke or blood clots in the lungs/legs, such as weakness on one side of the body, slurred speech, sudden vision changes, confusion, shortness of breath, chest pain, or calf pain/swelling. Tell your doctor right away if you develop symptoms of cancer of the uterus, such as unusual changes in your monthly period (e.g., amount or timing of bleeding), unusual vaginal discharge, or pain/pressure below your "belly button" (navel). Show More Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. Do not use this medicine together with blood thinners (eg, warfarin). Using this medicine while you are pregnant can harm your unborn baby. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (eg, condoms, spermicide) along with your pills. Women should use an effective form of birth control during treatment and for 9 months after the last dose. Men should use an effective form of birth control during treatment and for 6 months after the last dose to prevent pregnancy in a sexual partner. If a pregnancy occurs while using the medicine, tell your doctor right away.

    Tamoxifen safety

    MATERIAL SAFETY DATA SHEET - Pfizer, Soy Foods, Diet, and Tamoxifen - Oncology Nutrition DPG

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  3. Agency for Research on Cancer IARC lists Tamoxifen as a known human carcinogen. Canadian Standards Association CSA Approved Safety Glasses.

    • Guidelines for the use of tamoxifen in animal. - Western University.
    • Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant..
    • Tamoxifen Treatment in Animals Research Support - Boston University.

    Print Date 02/09/2016. 1. PRODUCT AND COMPANY IDENTIFICATION. 1.1 Product identifiers. Product name. Tamoxifen. Product Number. T5648. Brand. Is Tamoxifen safe to use in pregnancy or could it cause birth defects? Does it work as a form of contraception to prevent pregnancy? Tamoxifen official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more.

     
  4. VLadV Well-Known Member

    Toprol-XL is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. It has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The mechanism of the antihypertensive effects of beta-blocking agents is not fully known. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity. Metoprolol blocks the catecholamine-induced increases in heart rate, velocity and extent of myocardial contraction, and in blood pressure, metoprolol reduces the oxygen requirements of the heart at any given level of effort. Tthe precise mechanism for the beneficial effects of beta-blockers in heart failure is not known. Toprol-XL is specifically indicated for: the treatment of hypertension, either alone or in combination with other antihypertensive agents, the long-term treatment of angina pectoris and the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. Metoprolol Considerations for Use - American College of Cardiology Toprol-XL New FDA Drug Approval CenterWatch Metoprolol Uses, Dosage, Side Effects -
     
  5. Ruffn9ne Well-Known Member

    Zoloft Sertraline - Side Effects, Dosage, Interactions - Drugs Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors SSRIs.

    Multiple Meds and Kids What to Know Child Mind Institute
     
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