Macular society hydroxychloroquine

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  1. ehpehp XenForo Moderator

    Macular society hydroxychloroquine


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Therefore, disturbed renal or hepatic function might reduce HCQ clearance and increase the propensity for toxicity. Older age may also be associated with increased risk of macular toxicity, possibly due to the pre-existence of age-related macular changes that might not allow for the identification of early signs of toxicity. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Macular society hydroxychloroquine

    Hydroxychloroquine-Induced Retinal Toxicity - American., Retinal Physician - Hydroxychloroquine Maculopathy An.

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  5. The Macular Society supports those with Macular Degeneration, their families and their carers; offering counselling and other services, as well as funding crucial research into the disease.

    • Macular Society.
    • Retinal toxicity associated with chronic exposure to..
    • Recommendations on Screening for Chloroquine and..

    Hydroxychloroquine is a medicine that is effective in treating various long-term inflammatory disorders of the joints and skin. In general, it is a safe and cost-effective medication, particularly when compared to newer anti-inflammatory medicines which can more significant adverse effects on the body. Hydroxychloroquine is a medication used to treat several conditions, including active rheumatoid arthritis, juvenile idiopathic arthritis, discoid and systemic and cutaneous lupus erythematosus, solar urticarial. HCQ is widely used for the treatment of rheumatic diseases, particularly lupus and RA. It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy.

     
  6. zeng Moderator

    An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. falciparum; available in phosphate and sulfate forms. Malaria – Penn Medicine Chloroquine Definition of Chloroquine by Lexico Drug resistance in malaria - World Health Organization
     
  7. GAZIKK Moderator

    A variety of pharmacologic agents can cause toxicity to the retina. Plaquenil Side Effects Common, Severe, Long Term - Despite Plaquenil dosing recommendations, retinal toxicity. Retinal toxicity associated with chronic exposure to.
     
  8. Mrfun Guest

    Chloroquine MedlinePlus Drug Information Chloroquine phosphate may cause an upset stomach. Take chloroquine phosphate with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use chloroquine phosphate exactly as directed. Do not use more or less of it or use it more often than prescribed by your.

    Alfa Aesar Chloroquine diphosphate salt, 98% Fisher Scientific