Hi everyone, May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow improved my depression within a week. Where is chloroquine resistant malaria Fda chloroquine-primaquine pill malaria Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Namey on plaquenil substitute Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not. Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil Compared to Alternatives - Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. So please anyone, is there something else which can 'kill the bugs' inside me? DES-daughter ('67), Lyme's ('98), GAD ('98), Sjogren's ('02), hypothyroid ('04), endometriosis ('14), osteoarthritis ('16), blepharitis ('18), frozen shoulder ('19). The downside: I got a severe allergic reaction, eye trouble, enormous chills, constipation, weight gain and anorgasmia... Natural alternatives for plaquenil Alternatives to plaquenil Anti-Inflammatories discussions., Plaquenil Compared to Alternatives - Do you need a baseline eye exam before taking hydroxychloroquineChloroquine hydrochloride tabletsPlaquenil lupus fatiguePlaquenil and cosamine ds But Dr. Brownstein says natural remedies and healthy lifestyle changes can offer relief to patients and far are less risky than RA drugs, such as methotrexate, Humira, Imuran, and Enbrel. “These drugs all poison enzymes in the body which block the immune system function,” says Dr. Brownstein, author of “Overcoming Arthritis,” a holistic guide to treating autoimmune disorders and arthritis. Safe, Natural Alternatives to Arthritis Drugs Top Doc.. Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center. When the Patient Insists on Natural Therapies.. Here is a short list Prednisone, Imuran, Remicade, Methotrexate. Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur.