According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Macular society hydroxychloroquine Plaquenil cross eyes Chloroquine dose in child Chloroquine poisoning Chloroquine—the standard, effective drug for decades—costs about 10 U. S. cents per course of treatment for an adult. The new effective drugs— artemisinin combination therapy ACT 1 —today cost US$2.40 per course wholesale, and can be marked up to five times that amount in pharmacies in Africa. ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Read our disclaimer for details. ACT is the recommended first line medication for the treatment of uncomplicated Plasmadium falciparum malaria, especially in areas where resistance to Chloroquine CQ and /or sulpadoxine-pyrimethamine is above 10% WHO, 2006. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Act chloroquine Chloroquine Indications, Side Effects, Warnings -, ACT With Chloroquine, Amodiaquine & Sulphadoxine. Chloroquine for lupus A chloroquine dose of 600 mg base = 1,000 mg salt should be given initially, followed by 300 mg base = 500 mg salt at 6, 24, and 48 hours after the initial dose for a total chloroquine dose of 1,500 mg base =2,500 mg salt. CDC - Malaria - Diagnosis & Treatment United States.. Is Chloroquine Better than Artemisinin Combination Therapy.. Chloroquine Side Effects Common, Severe, Long Term.. In areas where chloroquine-resistant P. vivax has been identified, infections should be treated with an ACT, preferably one in which the partner medicine has a long half-life. With the exception of artesunate + sulfadoxine-pyrimethamine AS+SP combination, all ACTs are effective against the blood stage infections of P. vivax. Dec 13, 2018 Each ACT is a combination of two or more drugs that work against the malaria parasite in different ways. Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in.