Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Do you need to take pain meds with plaquenil Plaquenil mid back pain Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended. Mar 17, 2017 Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. A 71-year-old arthritic white woman, weighing 110 pounds, presented with a feared complaint of retinal hydroxychloroquine sulfate Plaquenil toxicity. She reported a light fog, just right of her central vision, worse in the right eye than the left. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil retinal toxicity night vision Plaquenil Related Eye Problems - Fraser Eye, Plaquenil Toxicity Screening Macula and Retina Institute c/o. Chloroquine lysosome sigma Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Multimodal Imaging in Plaquenil Toxicity. Retinal toxicity secondary to Plaquenil therapy.. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. In advanced cases of retinal toxicity from Plaquenil, there can be loss of visual acuity, peripheral vision, and night vision. Most documented cases of Plaquenil retinal toxicity are related to large cumulative lifetime doses over a period of many years. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as.