These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Prophylaxis for international travel to chloroquine resistant area Plaquenil and birth control Plaquenil coupon card Plaquenil making hair fall out Hydroxychloroquine side effects may range from mild to severe, although some side effects may go away with time. Some of the most common side effects of hydroxychloroquine include 3, 4 loss of appetite. diarrhea. headache. nausea. vomiting. stomach pain. shakiness. skin rash. More serious hydroxychloroquine side effects include 3, 4 Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Common side effects include headache; dizziness; loss of appetite; nausea; diarrhea; stomach pain; vomiting; nervousness; rash; Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects Plaquenil. For more information, ask your doctor or pharmacist. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Plaquenil side effects fatigue Hydroxychloroquine - thigh muscle weakness?, Plaquenil Side Effects - GoodRx Hydroxychloroquine sulfatr interactions May 25, 2010 Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. I have been on it for about. 3 months now. At first, I was nauseous for a week or so, which the dr. told me could be a side effect. Is extreme fatigue a side effect of Plaquenil?. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Nov 09, 2018 Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Hi, I've been taking Plaquenil for many years now and have never experienced any side effects or long term effects. But headache is listed as one of the "mild adverse effects". I would suggest that you try to split the dose as suggested. I've always taken 1 in the AM & 1 at night. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia.