Excessive production of melanin is responsible for this condition. Hyperpigmentation can occur on almost any part of the body, including the face, neck, hands, arms and legs. Plaquenil and prednisone together Hydroxychloroquine sulfate plaquenil side effects A 2018 review study suggests that the following natural treatments may be able to reduce the appearance of hyperpigmentation Aloe vera Share on Pinterest Aloe vera may help treat hyperpigmentation. Medical Treatment Options For Pigmentation And Spots. The treatment you undergo depends on the cause of your hyperpigmentation. If it is due to other health-related issues, treating the underlying problem can help reduce pigmentation. Some of the common treatments options include Microdermabrasion; Intense pulsed light IPL treatment; Chemical peel Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. External factors like excessive sun exposure, skin injury, burning, emotional stress or contact with certain chemicals can also cause hyperpigmentation. The root cause of excess melanin production is generally attributed to internal factors like hormonal changes in the body, pregnancy and various health problems. Natural treatments plaquenil hyperpigmentation How to Get Rid of Hyperpigmentation Top 10 Home Remedies, Home Remedies for Pigmentation How To Reduce Dark Spots Chloroquine phosphate flukesChloroquines impact on societyHydroxychloroquine long qt Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Hydroxychloroquine-Induced Pigmentation in Patients With.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Home Remedies To Get Rid Of Hyperpigmentation Naturally. To try your own version of this hyperpigmentation treatment at home Add a tablespoon of fresh black tea leaves to a cup of boiling distilled water. Steep for two hours and strain to remove the leaves. Soak a cotton ball in the tea water and apply to areas of hyperpigmentation, twice a day. Natural Ways to Reduce Hyperpigmentation. If you prefer to skip the topical creams and visits to the dermatologist, there are natural ways you can get the dark spots to fade. Some scars and dark spots will fade on their own, while others, such as birthmarks, can be reduced with the following natural ingredients Aloe vera Its high citric acid content makes it a natural bleaching agent. You can squeeze fresh lemon, dip a cotton ball in it, apply directly on the dark spots, leave it on for 15–20 minutes, and wash it off with cold water.