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    Oral: 15 to 20 mg/kg/day (based on the trimethoprim component) orally daily in 4 equally divided doses every 6 hours for 14 to 21 days IV: 15 to 20 mg/kg/day (based on the trimethoprim component) IV daily in 3 or 4 equally divided doses every 6 to 8 hours for up to 14 days Comments: -IV formulation: One investigator noted that a total daily dose of 10 to 15 mg/kg was sufficient in 10 adult patients with normal renal function. Use: For the treatment of documented Pneumocystis jiroveci pneumonia -Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally once a day -Maximum dose: The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim Use: For prophylaxis against P jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P jiroveci pneumonia Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg orally every 12 hours for 10 to 14 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for up to 14 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Use: For the treatment of severe or complicated urinary tract infections due to susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, and Proteus vulgaris Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 5 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for 5 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Comments: -The patient should be instructed to use extraordinary sanitary precautions since Shigella is transmitted by the fecal-oral route, primarily by hand-to-mouth contact. Use: For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 14 days Use: For acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when the physician deems that sulfamethoxazole and trimethoprim could offer some advantage over the use of a single antimicrobial agent Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 5 days Use: For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E coli Uncomplicated: Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours for 10 days Use: Uncomplicated pyelonephritis (off-label use) Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours for 10 to 14 days Use: Otitis media (off-label use in adults) Sulfamethoxazole-trimethoprim 400 mg-80 mg (1 single-strength tablet) orally once a day or 3 times a week at bedtime Comments: -Some clinicians recommend that their female patients take this low dose postcoitally or 3 times a week, whichever is less frequent. Therapy should be continued for as long as the patient is at risk for infection. Use: Cystitis prophylaxis (off-label use) Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally 2 times a day for at least 3 weeks Use: Granuloma inguinale (off-label use) 10 to 20 mg/kg (based on the trimethoprim component) IV every 6 to 12 hours Comments: Use in combination with chloramphenicol is an alternative for patients with beta-lactam allergy Use: Bacterial meningitis (off-label use) Cutaneous infection: 5 to 10 mg/kg/day (based on the trimethoprim component) IV or orally in 2 to 4 divided doses Severe infection (pulmonary/cerebral): 15 mg/kg/day (based on the trimethoprim component) in 2 to 4 divided doses for 3 to 4 weeks, then 10 mg/kg/day (based on the trimethoprim component) in 2 to 4 divided doses; may be initiated IV and converted to oral therapy (frequently converted to approximate dosages of oral solid dosage forms: 2 double strength tablets [320 mg-1600 mg] every 8 to 12 hours) Duration: Not well standardized; most experts recommend at least 6 months for local disease in immunocompetent patients and 6 to 12 months or more for immunocompromised patients or patients with CNS disease Comments: -Off-label use. Maximum plasma concentrations (Cmax) of 100 to 150 mcg/m L are recommended. Severe disease is often treated with addition of other agents, such as ceftriaxone, imipenem, or amikacin. Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours Duration: Acute, 10 to 14 days; chronic, 1 to 3 months Comments: -Off-label use. Ear Infection Medications - GoodRx Sulfa based antibiotics list - Things You Didn’t Know Keflex and Sulfa Allergies
     
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