Duloxetine pdf

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  1. nikki Moderator

    Duloxetine pdf


    Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Duloxetine is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old. Duloxetine is also used in adults to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy). Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Report any new or worsening symptoms to your doctor. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine.

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    CYMBALTA safely and effectively. See full prescribing stopping treatment with CYMBALTA. Do not use CYMBALTA information for CYMBALTA. within 14 days of stopping an MAOI intended to treat psychiatric. CYMBALTA Duloxetine Delayed-Release Capsules for Oral Use. disorders. In addition, do not start CYMBALTA in a patient who is Duloxetine and may require a dosage reduction of duloxetine • Cigarette smoking induces CYP450 1A2 and may reduce plasma levels of duloxetine, but dosage modifi cations are not recommended for smokers Inhibitors of CYP450 2D6, such as paroxetine, fl uoxetine, and quinidine, may increase plasma levels of duloxetine and Duloxetine is a balanced selective serotonin norepinephrine reuptake inhibitor SNRI which, in 2004, became the first agent to receive regulatory approval for the treatment of painful diabetic neuropathy in the US. This compound has no other significant receptor or channel activities other than the.

    It is a thiophene derivative and a selective neurotransmitter reuptake inhibitor for serotonin, norepinephrine, and to a lesser degree dopamine. It belongs to a class of heterocyclic antidepressants known as a serotonin–norepinephrine reuptake inhibitors (SNRI). Duloxetine failed to receive US approval for stress urinary incontinence amid concerns over liver toxicity and suicidal events; however, it was approved for this indication in the UK, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. The main uses of duloxetine are in major depressive disorder, generalized anxiety disorder, urinary incontinence, neuropathic pain, chronic musculoskeletal pain, and fibromyalgia. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. Initial dose: 20 mg orally twice a day Maintenance dose: 60 mg per day, given either once a day or as 30 mg orally twice a day Maximum dose: 120 mg orally per day Duration: Acute episodes generally require several months or more of sustained pharmacological therapy; a periodic review of the need for ongoing maintenance treatment and appropriate dosing is recommended. Comments: -Some patients may require 30 mg orally once day for 1 week, before increasing the dose to 60 mg per day -Data are lacking to show that doses greater than 60 mg per day confer any additional benefits. Use: Treatment of major depressive disorder (MDD) Initial dose: 30 mg orally once a day for 1 week Maintenance dose: 30 to 60 mg orally once a day Duration: Efficacy has been demonstrated for up to 3 months in placebo-controlled studies; effectiveness beyond this has not been demonstrated in longer studies; therefore, continued treatment should be based on individual patient response. Comments: -There is no evidence that doses greater than 60 mg per day confer additional benefit; higher doses are associated with a higher rate of side effects. Initial dose: 60 mg orally once a day Maintenance dose: 60 to 120 mg orally once a day Maximum dose: 120 mg orally once a day Duration: Episodes generally require several months or more of sustained pharmacological therapy; a periodic review of the need for ongoing maintenance treatment and appropriate dosing is recommended. Comments: -Some patients may require 30 mg orally once day for 1 week, before increasing the dose to 60 mg per day -The dose may be increased in increments of 30 mg once a day if clinically appropriate -There is no evidence that doses greater than 60 mg per day confer additional benefit Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day Duration: -Diabetic peripheral neuropathy pain: Efficacy beyond 12 weeks has not been established; effectiveness should be based on individual patient response. -Chronic musculoskeletal pain: Efficacy beyond 13 weeks has not been established.

    Duloxetine pdf

    Duloxetine Uses, Side Effects, Dosage, Warnings -, DULOXETINE -

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  5. Duloxetine is a medication used to treat depression, anxiety, and chronic pain in adults. Duloxetine belongs to a group of antidepressant medications known as serotonin-norepinephrine reuptake inhibitors SNRIs.

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    CYMBALTAsafely and effectively. See full prescribing information for CYMBALTA. CYMBALTADuloxetine Delayed-Release Capsulesfor Oral Use. Initial U. S. Approval 2004 WARNING SUICIDALTHOUGHTSAND BEHAVIORS See full prescribing information for complete boxed warning. • Increased risk of suicidal thinking and behavior in children, Detailed Duloxetine dosage information for adults, the elderly and children. Includes dosages for Depression, Pain, Fibromyalgia and more; plus renal. Summary of Findings – May 25, 2011 – Duloxetine Duloxetine Is Duloxetine effective in reducing pain and improving function in patients with symptomatic OA knee pain compared to placebo? Is duloxetine well tolerated by these patients? Step 1 Search results We found the most recent randomized placebo-controlled trial Chappell, 2011 which

     
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