Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil visual field guidelines Do you need to take pain meds with plaquenil The risk of retinal damages is small with daily doses of up to 6.5 mg/kg ideal lean body weight. Exceeding the recommended daily dose sharply increases the risk of retinal toxicity. Significant risk factors for toxic retinopathy reported during long-term ≥5 years treatment with hydroxychloroquine include daily doses greater than 6.5 The Journal of Rheumatology Volume 44, no. 11 Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine Jung-Yoon Choe Ji-Won Kim, Yoon Young Kim, Hwajeong Lee, Sung-Hoon Park, Seong-Kyu Kim and Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Because it presents potential secondary effects including irreversible maculopathy, knowledge of incidence, risk factors, drug toxicity and protocol screening of the patients it represents important data for the ophthalmologists. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Incidence of retinal toxicity from plaquenil Hydroxychloroquine Plaquenil Toxicity and., Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine High risk plaquenil icd 10 Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Focus on Eyes Long-term Plaquenil intake can affect your vision. Retinal toxicity associated with chronic exposure to.. Hydroxychloroquine-Induced Retinal Toxicity - American.. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of.