Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Can you take plaquenil if you are allergic to sulfate Plaquenil related to insomnia Patients assistance for hydroxychloroquine General antimicrobial mechanism of action of chloroquine. Chloroquine accumulates in very high concentrations in the parasite food vacuole Geary et al. 1986. Once in the food vacuole, chloroquine is thought to inhibit the detoxification of heme. Chloroquine becomes protonated to CQ 2+ because the digestive vacuole is acidic pH 4.7 In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. What is the mechanism of action of chloroquine Chloroquine Modes of action of an undervalued drug., Antimalarial Drug Mechanism of Action What is Chloroquine. Retinal chloroquine retinopathyLupus treatment hydroxychloroquineTrialnet hydroxychloroquine Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. It increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. Chloroquine phosphate C18H32ClN3O8P2 - PubChem. Mechanisms of action of hydroxychloroquine and chloroquine.. PDF Malaria Mode of action of chloroquine and mechanism.. What is the mechanism of action of chloroquine? Chloroquine concentrates in parasite food vacuoles and prevents parasitic detoxification of heme to non-toxic hemozoin. This causes lysis of both the parasite and the RBC. Chloroquine has a negative inotropic action, inhibits spontaneous diastolic depolarization, slows conduction, lengthens the effective refractory period and raises the electrical threshold. This results in depression of contractility, impairment of conductivity, decrease of excitability, but with possible abnormal stimulus re-entry mechanism. Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA.