The disease is transmitted by the bite of a mosquito. The Chloroquine drug is also used for treating liver disease caused by protozoa. Concurrent administration of chloroquine Best alternative to plaquenil for lupus A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. In Tanzania, chloroquine was replaced by sulphadoxine- pyrimethamine SP as a first-line for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP lasted for only 5. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. However, it has no effect on pre and exo-erythrocytic phases of the parasite and does not prevent relapses in vivax and ovale malaria. It is rapidly acting erythrocytic schizonticide; controls most clinical attacks in 1-2 days with disappearance of parasites from peripheral blood. Chloroquine ineffective on exo Current Trends of Anti-malarial Drugs, Detection of mutations associated with artemisinin resistance. Is hydroxychloroquine contraindicated in pregnancyChloroquine irreducible complexityLupus and pregnancy plaquenilPlaquenil 400 mg bugiardinoPlaquenil 200 mg tablets side effects Antimalarial Drugs. Chloroquine. Chloroquine Aralen is one of several 4-aminoquino-line derivatives that display antimalarial activity. Chloroquine is particularly effective against intraeryth-rocytic forms because it is concentrated within the par-asitized erythrocyte. Antimalarial Drugs - BrainKart. CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and.. Chloroquine - Wikipedia. Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality. Chloroquine A drug used against malaria for both prevention and treatment. A very safe and inexpensive drug, its value has been compromised by the emergence of chloroquine-resistant malaria parasites. Cinchonism Side effects from quinine or quinidine. Includes tinnitus, headache, nausea, diarrhea, altered auditory acuity, and blurred vision. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial.