Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil risk of death What durg class is chloroquine 60 increase in malaria deaths after chloroquine failure Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. Fingolimod Major Avoid coadministration of hydroxychloroquine and fingolimod. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen whilst considering the drug's safety profile. RESULTS Hydroxychloroquine EC50=0.72 μM was found to be more potent than chloroquine EC50=5.47 μM in vitro. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine sulphate indications Hydroxychloroquine Professional Patient Advice -, Plaquenil hydroxychloroquine sulfate dose, indications. Plaquenil and ace inhibitorPlaquenil immune complexes Common hydroxychloroquine side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Hydroxychloroquine Uses, Dosage & Side Effects -. In Vitro Antiviral Activity and Projection of Optimized.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Find patient medical information for Hydroxychloroquine Sulfate Bulk on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Signs of low blood sugar like dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating.