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    Ovarian cancer is one of the most common lethal gynecological malignancies world-wide. Despite an initial 70–80 % response rate, most patients relapse within 1–2 years and develop chemo-resistance. Hence, the identification of novel drugs or the repositioning of known drugs to re-sensitize ovarian cancer cells to existing chemotherapy regimens is needed. Here, we evaluated the effect of metformin (an anti-diabetic drug) on ovarian cancer cells, based on its putative effect on other solid tumors. Primary cultures of epithelial ovarian cancer cells established from ascitic fluids of untreated ovarian cancer patients and the SKOV-3 ovarian cancer-derived cell line were used. The respective cells were treated with metformin, carboplatin and paclitaxel alone and its various combinations and their effects, including the ability to induce apoptosis, were examined. Concomitantly, the cells were assessed for the expression of several apoptosis-related m RNAs and proteins using quantitative real time PCR, flowcytometry and Western blotting. Study adds diabetes drug to current state-of-the-art therapy for patients. Metformin and Chemotherapy in Treating Patients With Stage III-IV. Diabetes Drug May Help Ovarian Cancer Patients Live Longer
     
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