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    Elderly patients are more likely to have decreased renal function; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases Not for use in patients 80 years unless normal renal function established Initial and maintenance dosing of metformin should be conservative in patients with advanced age due to the potential for decreased renal function in this population Controlled clinical studies of metformin did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients Asthenia Diarrhea Flatulence Weakness Myalgia Upper respiratory tract infection Hypoglycemia GI complaints Lactic acidosis (rare) Low serum vitamin B-12 Nausea/vomiting Chest discomfort Chills Dizziness Abdominal distention Constipation Heartburn Dyspepsia 5 mmol/L), decreased blood p H, electrolyte disturbances with an increased anion gap, and an increased lactate/pyruvate ratio; when metformin is implicated as the cause of lactic acidosis, metformin plasma concentrations 5 mcg/m L are generally found Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment; if metformin-associated lactic acidosis is suspected, immediately discontinue Patients with CHF requiring pharmacologic management, in particular those with unstable or acute CHF who are at risk for hypoperfusion and hypoxemia, are at an increased risk for lactic acidosis; the risk for lactic acidosis increases with the degree of renal dysfunction and the patient’s age Do not start in patients aged 80 years or older unless Cr Cl demonstrates that renal function is not reduced, because these patients are more susceptible to developing lactic acidosis; metformin should be promptly withheld in the presence of any condition associated with hypoxemia, dehydration, or sepsis Should generally be avoided in patients with clinical or laboratory evidence of hepatic disease; patients should be cautioned against excessive alcohol intake, either acute or chronic, during metformin therapy because alcohol potentiates the effects of metformin on lactate metabolism Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an e GFR between 30-60 m L/minute/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast The onset of lactic acidosis often is subtle and accompanied by nonspecific symptoms (eg, malaise, myalgias, respiratory distress, increasing somnolence, nonspecific abdominal distress); with marked acidosis, hypothermia, hypotension, and resistant bradyarrhythmias may occur; patients should be instructed regarding recognition of these symptoms and told to notify their physician immediately if the symptoms occur; metformin should be withdrawn until the situation is clarified; serum electrolytes, ketones, blood glucose, and, if indicated, blood p H, lactate levels, and even blood metformin levels may be useful Once a patient is stabilized on any dose level of metformin, GI symptoms, which are common during initiation of therapy, are unlikely to be drug related; later occurrences of GI symptoms could be due to lactic acidosis or other serious disease Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis who is lacking evidence of ketoacidosis (ketonuria and ketonemia); lactic acidosis is a medical emergency that must be treated in a hospital setting; in a patient with lactic acidosis who is taking metformin, the drug should be discontinued immediately and general supportive care measures promptly instituted; metformin is highly dialyzable (clearance up to 170 m L/min under good hemodynamic conditions); prompt hemodialysis is recommended to correct the acidosis and to remove the accumulated metformin; such management often results in prompt reversal of symptoms and recovery Increased risk of severe hypoglycemia especially in elderly, debilitated or malnourished, adrenal or pituitary insufficiency, dehydration, heavy alcohol use, hypoxic states, hepatic/renal impairment, stress due to infection, fever, trauma, or surgery Concomitant administration of insulin and insulin secretagogues (e.g., sulfonylurea) may increase risk of hypoglycemia; therefore, a lower dose of insulin or insulin secretagogue may be required to minimize risk of hypoglycemia when used in combination with metformin Withholding of food and fluids during surgical or other procedures may increase risk for volume depletion, hypotension, and renal impairment; therapy should be temporarily discontinued while patients have restricted food and fluid intake Rare lactic acidosis may occur due to metformin accumulation; fatal in approximately 50% of cases; risk increases with age, degree of renal dysfunction, and with unstable or acute CHF; if metformin-associated lactic acidosis suspected, general supportive measures should be instituted promptly in a hospital setting, along with immediate discontinuation of therapy; in patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct acidosis and remove accumulated metformin (metformin hydrochloride is dialyzable, with a clearance of up to170 m L/minute under good hemodynamic conditions); hemodialysis has often resulted in reversal of symptoms and recovery Possible increased risk of CV mortality May cause ovulation in anovulatory and premenopausal PCOS patients May be necessary to discontinue therapy with metformin and administer insulin if patient is exposed to stress (fever, trauma, infection), or experiences diabetic ketoacidosis Several of the postmarketing cases of metformin-associated lactic acidosis occurred in setting of acute congestive heart failure (particularly when accompanied by hypoperfusion and hypoxemia); cardiovascular collapse (shock) acute myocardial infarction, sepsis, and other conditions associated with hypoxemia have been associated with lactic acidosis and may also cause prerenal azotemia; discontinue therapy when such events occur May impair vitamin B12 or calcium intake/absorption; monitor B12 serum concentrations periodically with long-term therapy Not indicated for use in patients with type 1 diabetes mellitus that are insulin dependent due to lack of efficacy Withhold in patients with dehydration and/or prerenal azotemia Conclusive evidence of macrovascular risk reduction with metformin not established Limited data with in pregnant women are not sufficient to determine drug-associated risk for major birth defects or miscarriage; published studies with metformin use during pregnancy have not reported a clear association with metformin and major birth defect or miscarriage risk; poorly-controlled diabetes mellitus in pregnancy increases maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, stillbirth and delivery complications; poorly controlled diabetes mellitus increases the fetal risk for major birth defects, stillbirth, and macrosomia related morbidity Limited published studies report that metformin is present in human milk; however, there is insufficient information to determine effects of metformin on breastfed infant and no available information on effects of metformin on milk production; therefore, developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from the underlying maternal condition The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. cytotec mexico La metformina es uno de los medicamentos que a pesar del paso del tiempo (vigente desde hace 45 años), sigue siendo una opción recomendada para el tratamiento de la Diabetes. Su función principal es reducir la producción de glucosa del hígado, pues ayuda a que el tejido muscular aproveche mejor la glucosa, así como favorecer el efecto de la insulina producida por el organismo. Como todo medicamento, la metformina puede presentar efectos secundarios que afectan de manera diferente a cada persona, aunque no son muy frecuentes. Algunos de los efectos secundarios más comunes, que afectan a una de cada diez personas que la toman, son náuseas, diarrea, vómito, dolor abdominal y pérdida de apetito. Otro efecto menos común que llega a afectar a una de cada cien personas, es una variabilidad en el sentido de gusto, generalmente a metal. Hay otros efectos, éstos muy raros, que se presentan solo en 1 de cada 10 mil personas: niveles elevados de ácido láctico en la sangre, reacciones en la piel, irritación y comezón, dificultad para absorber la vitamina B-12 (tomando metformina a largo plazo). Si has tomado metformina y empiezas sentir dificultad para respirar, aletargamiento, mareos y confusión, debes consultar a tu médico lo más pronto posible, ya que estos son síntomas de acidosis láctica, una condición seria que, aunque muy raramente, puede ser provocada por la metformina.

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    Metformina Infórmate sobre efectos secundarios, dosis, precauciones y más en MedlinePlus. can metformin cause hypoglycemia Videoconsejo sanitario sobre la metformina, qué es, cuándo y cómo debemos tomarla. Videoconsejo impartido por el farmacéutico Iván. Many translated example sentences containing "metformin" – Spanish-English dictionary and search engine for Spanish translations.

    El metformin del biguanide (dimethylbiguanide) fue introducido inicialmente para el uso en el tratamiento del tipo - diabetes 2 mellitus a finales de los años 50. Esta droga se considera hoy ser el agente de primera clase y el “patrón oro” para la mayoría de la gente con el tipo - diabetes 2. Se ha estimado que el número de gente anual que recibe las recetas para el metformin por todo el mundo es más de 120 millones. La eficacia y las ventajas del tratamiento del metformin en tipo - la diabetes 2 ha sido confirmada por estudios en grande y reconocida por muchas declaraciones del consenso. No obstante, un filete grande de contraindicaciones puede aumentar la incidencia de efectos nocivos serios, que impide a muchos pacientes de tomar metformin. Tres contraindicaciones determinadas al uso del metformin se han sugerido. Incluyen la debilitación renal con los niveles elevados de la creatina del suero ( de 136 mmol/l en hombres y 124 mmol/l en mujeres) o la tolerancia anormal de la creatinina, insuficiencia cardiaca congestiva que requiere el tratamiento farmacológico y la edad avanzada (más de 80 años de edad). Hace unos días les amenacé con dedicar una serie de entradas a la diabetes mellitus y sus circunstancias. La metformina, de la familia de las biguanidas -de las biguanidas de toda la vida- desde que nació en 1957, como mi padre, tiene el noble objetivo de controlar la glucosa, también conocida como azúcar, en sangre. He decidido empezar por la metformina porque este fármaco es el abanderado de la diabetes tipo II. Se emplea como fármaco de elección para el tratamiento de la diabetes tipo II, especialmente en aquellos casos en los que el paciente tiene sobrepeso. No hablar de metformina en el tratamiento de la diabetes sería como hablar de superhéroes sin mencionar a Superman, como hablar de Operación Triunfo sin mencionar a Bisbal o como hablar de Presidentes de Gobierno en España sin mencionar a… Es decir, en ausencia de contraindicaciones, las probabilidades de salir de consulta con una receta de metformina bajo el brazo si a usted le diagnostican diabetes y no mejora con dieta y ejercicio, son elevadas. De hecho, actualmente se apoya también el empleo de metformina en un estado llamado “prediabetes”, a modo de prevención. Distintos estudios muestran el potencial de la metformina con prometedores resultados en otras patologías entre las que destacan dos: – Síndrome de ovario poliquístico y la infertilidad. Hoy nos centraremos exclusivamente en su uso frente a la diabetes. TRES son las virtudes antihiperglucemiantes de la metformina (es decir, que evitan el aumento de glucosa en sangre) en TRES lugares distintos del organismo: 1- HÍGADO: Reduce la producción de glucosa mediante dos vías: evitando la gluconeogénesis (“fabricación” de glucosa desde cero) y la glucógenolisis (la división “en cachitos” de glucógeno dando lugar a glucosa). El glucógeno es como un tren de mercancías donde se va almacenando el azúcar para cuando hace falta tirar de las reservas.

    Metformin en espanol

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    El metformin del biguanide dimethylbiguanide fue introducido inicialmente para el uso en el tratamiento del tipo - diabetes 2 mellitus a finales de los años 50. viagra use by date Episodio #1086 El daño que no conoces sobre la metformina - Duration. MetabolismoTV 637,707 views ·. Play next; Play now. Para qué sirve la metformina? Es el fármaco más prescrito para la diabetes tipo II entre otras cosas, porque no produce bajadas de azúcar.

     
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