Zovirax is a prescription medication drug (also known under the generic drug name, Acyclovir) that is used to treat cold sores, shingles, chickenpox and sometimes genital herpes. These infections are caused by the herpes simplex and herpes zoster viruses, and though the drug does not cure the infections, Acyclovir can decrease the severity and length of the outbreaks. Zovirax is the oldest of the antiviral medications out there, as it has been available since 1982 in the topical form as an ointment cream, and since 1985 as a pill. The cream formulation for topical administration should be applied 5 times per day for 4 days. Now Acyclovir is available in a generic form and is the only antiviral available as intravenous medication. Valtrex, manufactured by Glaxo Smith Kline, was approved by the FDA in 1995 and was the 2nd antiviral medication to come to market in the USA. 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